| 2022-01-15 | UFC on ESPN: Kattar vs. Chikadze | UFC Apex · Las Vegas, Nevada | Calvin Kattar def. Giga Chikadze | 10 |
| 2022-01-22 | UFC 270: Ngannou vs. Gane | Honda Center · Anaheim, California | Francis Ngannou def. Ciryl Gane title | 11 |
| 2022-02-05 | UFC Fight Night: Hermansson vs. Strickland | UFC Apex · Las Vegas, Nevada | Sean Strickland def. Jack Hermansson | 13 |
| 2022-02-12 | UFC 271: Adesanya vs. Whittaker 2 | Toyota Center · Houston, Texas | Israel Adesanya def. Robert Whittaker title | 14 |
| 2022-02-19 | UFC Fight Night: Walker vs. Hill | UFC Apex · Las Vegas, Nevada | Jamahal Hill def. Johnny Walker | 12 |
| 2022-02-26 | UFC Fight Night: Makhachev vs. Green | UFC Apex · Las Vegas, Nevada | Islam Makhachev def. Bobby Green | 11 |
| 2022-03-05 | UFC 272: Covington vs. Masvidal | T-Mobile Arena · Las Vegas, Nevada | Colby Covington def. Jorge Masvidal | 13 |
| 2022-03-12 | UFC Fight Night: Santos vs. Ankalaev | UFC Apex · Las Vegas, Nevada | Magomed Ankalaev def. Thiago Santos | 14 |
| 2022-03-19 | UFC Fight Night: Volkov vs. Aspinall | The O2 Arena · London, England | Tom Aspinall def. Alexander Volkov | 12 |
| 2022-03-26 | UFC on ESPN: Blaydes vs. Daukaus | Nationwide Arena · Columbus, Ohio | Curtis Blaydes def. Chris Daukaus | 12 |
| 2022-04-09 | UFC 273: Volkanovski vs. The Korean Zombie | VyStar Veterans Memorial Arena · Jacksonville, Florida | Alexander Volkanovski def. Chan Sung Jung title | 12 |
| 2022-04-16 | UFC on ESPN: Luque vs. Muhammad 2 | UFC Apex · Las Vegas, Nevada | Belal Muhammad def. Vicente Luque | 14 |
| 2022-04-23 | UFC Fight Night: Lemos vs. Andrade | UFC Apex · Las Vegas, Nevada | Jéssica Andrade def. Amanda Lemos | 11 |
| 2022-04-30 | UFC on ESPN: Font vs. Vera | UFC Apex · Las Vegas, Nevada | Marlon Vera def. Rob Font | 11 |
| 2022-05-07 | UFC 274: Oliveira vs. Gaethje | Footprint Center · Phoenix, Arizona | Charles Oliveira def. Justin Gaethje title | 14 |
| 2022-05-14 | UFC on ESPN: Błachowicz vs. Rakić | UFC Apex · Las Vegas, Nevada | Jan Błachowicz def. Aleksandar Rakić | 11 |
| 2022-05-21 | UFC Fight Night: Holm vs. Vieira | UFC Apex · Las Vegas, Nevada | Ketlen Vieira def. Holly Holm | 11 |
| 2022-06-04 | UFC Fight Night: Volkov vs. Rozenstruik | UFC Apex · Las Vegas, Nevada | Alexander Volkov def. Jairzinho Rozenstruik | 14 |
| 2022-06-12 | UFC 275: Teixeira vs. Procházka | Singapore Indoor Stadium · Kallang | Jiří Procházka def. Glover Teixeira title | 11 |
| 2022-06-18 | UFC on ESPN: Kattar vs. Emmett | Moody Center · Austin, Texas | Josh Emmett def. Calvin Kattar | 13 |
| 2022-06-25 | UFC on ESPN: Tsarukyan vs. Gamrot | UFC Apex · Las Vegas, Nevada | Mateusz Gamrot def. Arman Tsarukyan | 12 |
| 2022-07-02 | UFC 276: Adesanya vs. Cannonier | T-Mobile Arena · Las Vegas, Nevada | Israel Adesanya def. Jared Cannonier title | 12 |
| 2022-07-09 | UFC on ESPN: dos Anjos vs. Fiziev | UFC Apex · Las Vegas, Nevada | Rafael Fiziev def. Rafael dos Anjos | 11 |
| 2022-07-16 | UFC on ABC: Ortega vs. Rodríguez | UBS Arena · Elmont, New York | Yair Rodríguez def. Brian Ortega | 12 |
| 2022-07-23 | UFC Fight Night: Blaydes vs. Aspinall | The O2 Arena · London, England | Curtis Blaydes def. Tom Aspinall | 14 |
| 2022-07-30 | UFC 277: Peña vs. Nunes 2 | American Airlines Center · Dallas, Texas | Amanda Nunes def. Julianna Peña title | 13 |
| 2022-08-06 | UFC on ESPN: Santos vs. Hill | UFC Apex · Las Vegas, Nevada | Jamahal Hill def. Thiago Santos | 10 |
| 2022-08-13 | UFC on ESPN: Vera vs. Cruz | Pechanga Arena · San Diego, California | Marlon Vera def. Dominick Cruz | 13 |
| 2022-08-20 | UFC 278: Usman vs. Edwards 2 | Vivint Arena · Salt Lake City, Utah | Leon Edwards def. Kamaru Usman title | 12 |
| 2022-09-03 | UFC Fight Night: Gane vs. Tuivasa | Accor Arena · Paris | Ciryl Gane def. Tai Tuivasa | 12 |
| 2022-09-10 | UFC 279: Diaz vs. Ferguson | T-Mobile Arena · Las Vegas, Nevada | Nate Diaz def. Tony Ferguson | 13 |
| 2022-09-17 | UFC Fight Night: Sandhagen vs. Song | UFC Apex · Las Vegas, Nevada | Cory Sandhagen def. Song Yadong | 13 |
| 2022-10-01 | UFC Fight Night: Dern vs. Yan | UFC Apex · Las Vegas, Nevada | Yan Xiaonan def. Mackenzie Dern | 11 |
| 2022-10-15 | UFC Fight Night: Grasso vs. Araújo | UFC Apex · Las Vegas, Nevada | Alexa Grasso def. Viviane Araújo | 11 |
| 2022-10-22 | UFC 280: Oliveira vs. Makhachev | Etihad Arena · Abu Dhabi | Islam Makhachev def. Charles Oliveira title | 12 |
| 2022-10-29 | UFC Fight Night: Kattar vs. Allen | UFC Apex · Las Vegas, Nevada | Arnold Allen def. Calvin Kattar | 11 |
| 2022-11-05 | UFC Fight Night: Rodriguez vs. Lemos | UFC Apex · Las Vegas, Nevada | Amanda Lemos def. Marina Rodriguez | 11 |
| 2022-11-12 | UFC 281: Adesanya vs. Pereira | Madison Square Garden · New York City, New York | Alex Pereira def. Israel Adesanya title | 14 |
| 2022-11-19 | UFC Fight Night: Nzechukwu vs. Cuțelaba | UFC Apex · Las Vegas, Nevada | Kennedy Nzechukwu def. Ion Cuțelaba | 11 |
| 2022-12-03 | UFC on ESPN: Thompson vs. Holland | Kia Center · Orlando, Florida | Stephen Thompson def. Kevin Holland | 14 |
| 2022-12-10 | UFC 282: Błachowicz vs. Ankalaev | T-Mobile Arena · Las Vegas, Nevada | Jan Błachowicz vs. Magomed Ankalaev title | 12 |
| 2022-12-17 | UFC Fight Night: Cannonier vs. Strickland | UFC Apex · Las Vegas, Nevada | Jared Cannonier def. Sean Strickland | 13 |