| 2022-08-06 | UFC on ESPN: Santos vs. Hill | Light Heavyweight | Jamahal Hill def. Thiago Santos | TKO (punches and elbows) | 4 | 2:31 |
| 2022-03-12 | UFC Fight Night: Santos vs. Ankalaev | Light Heavyweight | Magomed Ankalaev def. Thiago Santos | Decision (unanimous) (49–46, 49–46, 48–47) | 5 | 5:00 |
| 2021-10-02 | UFC Fight Night: Santos vs. Walker | Light Heavyweight | Thiago Santos def. Johnny Walker | Decision (unanimous) (48–47, 48–47, 48–47) | 5 | 5:00 |
| 2021-03-06 | UFC 259: Błachowicz vs. Adesanya | Light Heavyweight | Aleksandar Rakić def. Thiago Santos | Decision (unanimous) (29–28, 29–28, 30–27) | 3 | 5:00 |
| 2020-11-07 | UFC on ESPN: Santos vs. Teixeira | Light Heavyweight | Glover Teixeira def. Thiago Santos | Submission (rear-naked choke) | 3 | 1:49 |
| 2019-07-06 | UFC 239: Jones vs. Santos | Light Heavyweight | Jon Jones def. Thiago Santos title | Decision (split) (47–48, 48–47, 48–47) | 5 | 5:00 |
| 2019-02-23 | UFC Fight Night: Błachowicz vs. Santos | Light Heavyweight | Thiago Santos def. Jan Błachowicz | TKO (punches) | 3 | 0:39 |
| 2018-12-08 | UFC 231: Holloway vs. Ortega | Light Heavyweight | Thiago Santos def. Jimi Manuwa | KO (punch) | 2 | 0:41 |
| 2018-09-22 | UFC Fight Night: Santos vs. Anders | Light Heavyweight | Thiago Santos def. Eryk Anders | TKO (referee stoppage) | 3 | 5:00 |
| 2018-08-04 | UFC 227: Dillashaw vs. Garbrandt 2 | Middleweight | Thiago Santos def. Kevin Holland | Decision (unanimous) (29–27, 29–27, 29–26) | 3 | 5:00 |
| 2018-04-21 | UFC Fight Night: Barboza vs. Lee | Middleweight | David Branch def. Thiago Santos | KO (punches) | 1 | 2:30 |
| 2018-02-03 | UFC Fight Night: Machida vs. Anders | Middleweight | Thiago Santos def. Anthony Smith | TKO (body kick and punches) | 2 | 1:03 |
| 2017-10-28 | UFC Fight Night: Brunson vs. Machida | Middleweight | Thiago Santos def. Jack Hermansson | TKO (jumping body kick and punches) | 1 | 4:59 |
| 2017-07-08 | UFC 213: Romero vs. Whittaker | Middleweight | Thiago Santos def. Gerald Meerschaert | TKO (punches) | 2 | 2:04 |
| 2017-02-19 | UFC Fight Night: Lewis vs. Browne | Middleweight | Thiago Santos def. Jack Marshman | TKO (spinning heel kick and punches) | 2 | 2:21 |
| 2016-09-24 | UFC Fight Night: Cyborg vs. Länsberg | Middleweight | Eric Spicely def. Thiago Santos | Submission (rear-naked choke) | 1 | 2:58 |
| 2016-07-09 | UFC 200: Tate vs. Nunes | Middleweight | Gegard Mousasi def. Thiago Santos | KO (punches) | 1 | 4:32 |
| 2016-05-14 | UFC 198: Werdum vs. Miocic | Middleweight | Thiago Santos def. Nate Marquardt | KO (punches) | 1 | 3:39 |
| 2015-12-10 | UFC Fight Night: Namajunas vs. VanZant | Middleweight | Thiago Santos def. Elias Theodorou | Decision (unanimous) (29–28, 29–27, 29–27) | 3 | 5:00 |
| 2015-06-27 | UFC Fight Night: Machida vs. Romero | Middleweight | Thiago Santos def. Steve Bossé | KO (head kick) | 1 | 0:29 |
| 2015-01-31 | UFC 183: Silva vs. Diaz | Middleweight | Thiago Santos def. Andy Enz | TKO (punches) | 1 | 1:56 |
| 2014-07-05 | UFC 175: Weidman vs. Machida | Middleweight | Uriah Hall def. Thiago Santos | Decision (unanimous) (29–28, 29–28, 29–28) | 3 | 5:00 |
| 2014-03-23 | UFC Fight Night: Shogun vs. Henderson 2 | Catchweight | Thiago Santos def. Ronny Markes | TKO (body kick and punches) | 1 | 0:53 |
| 2013-08-03 | UFC 163: Aldo vs. Korean Zombie | Middleweight | Cezar Ferreira def. Thiago Santos | Submission (guillotine choke) | 1 | 0:47 |