| 2026-03-28 | UFC Fight Night: Adesanya vs. Pyfer | Middleweight | Joe Pyfer def. Israel Adesanya | TKO (punches) | 2 | 4:18 |
| 2025-02-01 | UFC Fight Night: Adesanya vs. Imavov | Middleweight | Nassourdine Imavov def. Israel Adesanya | TKO (punches) | 2 | 0:30 |
| 2024-08-18 | UFC 305: du Plessis vs. Adesanya | Middleweight | Dricus du Plessis def. Israel Adesanya title | Submission (face crank) | 4 | 3:38 |
| 2023-09-10 | UFC 293: Adesanya vs. Strickland | Middleweight | Sean Strickland def. Israel Adesanya title | Decision (unanimous) (49–46, 49–46, 49–46) | 5 | 5:00 |
| 2023-04-08 | UFC 287: Pereira vs. Adesanya 2 | Middleweight | Israel Adesanya def. Alex Pereira title | KO (punches) | 2 | 4:21 |
| 2022-11-12 | UFC 281: Adesanya vs. Pereira | Middleweight | Alex Pereira def. Israel Adesanya title | TKO (punches) | 5 | 2:01 |
| 2022-07-02 | UFC 276: Adesanya vs. Cannonier | Middleweight | Israel Adesanya def. Jared Cannonier title | Decision (unanimous) (49–46, 49–46, 50–45) | 5 | 5:00 |
| 2022-02-12 | UFC 271: Adesanya vs. Whittaker 2 | Middleweight | Israel Adesanya def. Robert Whittaker title | Decision (unanimous) (48–47, 48–47, 49–46) | 5 | 5:00 |
| 2021-06-12 | UFC 263: Adesanya vs. Vettori 2 | Middleweight | Israel Adesanya def. Marvin Vettori title | Decision (unanimous) (50–45, 50–45, 50–45) | 5 | 5:00 |
| 2021-03-06 | UFC 259: Błachowicz vs. Adesanya | Light Heavyweight | Jan Błachowicz def. Israel Adesanya title | Decision (unanimous) (49–46, 49–45, 49–45) | 5 | 5:00 |
| 2020-09-27 | UFC 253: Adesanya vs. Costa | Middleweight | Israel Adesanya def. Paulo Costa title | TKO (punches) | 2 | 3:59 |
| 2020-03-07 | UFC 248: Adesanya vs. Romero | Middleweight | Israel Adesanya def. Yoel Romero title | Decision (unanimous) (48–47, 48–47, 49–46) | 5 | 5:00 |
| 2019-10-05 | UFC 243: Whittaker vs. Adesanya | Middleweight | Israel Adesanya def. Robert Whittaker title | KO (punches) | 2 | 3:33 |
| 2019-04-13 | UFC 236: Holloway vs. Poirier 2 | Middleweight | Israel Adesanya def. Kelvin Gastelum title | Decision (unanimous) (48–46, 48–46, 48–46) | 5 | 5:00 |
| 2019-02-10 | UFC 234: Adesanya vs. Silva | Middleweight | Israel Adesanya def. Anderson Silva | Decision (unanimous) (29–28, 30–27, 30–27) | 3 | 5:00 |
| 2018-11-03 | UFC 230: Cormier vs. Lewis | Middleweight | Israel Adesanya def. Derek Brunson | TKO (knees and punches) | 1 | 4:51 |
| 2018-07-06 | The Ultimate Fighter: Undefeated Finale | Middleweight | Israel Adesanya def. Brad Tavares | Decision (unanimous) (49–46, 50–45, 50–45) | 5 | 5:00 |
| 2018-04-14 | UFC on Fox: Poirier vs. Gaethje | Middleweight | Israel Adesanya def. Marvin Vettori | Decision (split) (29–28, 28–29, 29–28) | 3 | 5:00 |
| 2018-02-11 | UFC 221: Romero vs. Rockhold | Middleweight | Israel Adesanya def. Rob Wilkinson | TKO (knees and punches) | 2 | 3:37 |