| 2026-09-12 | UFC Fight Night: Silva vs. Delgado | Heavyweight | Curtis Blaydes def. Waldo Cortes-Acosta | Decision (unanimous) (29–28, 29–28, 29–28) | 3 | 5:00 |
| 2026-04-11 | UFC 327: Procházka vs. Ulberg | Heavyweight | Josh Hokit def. Curtis Blaydes | Decision (unanimous) (29–28, 29–28, 29–28) | 3 | 5:00 |
| 2025-06-21 | UFC on ABC: Hill vs. Rountree Jr. | Heavyweight | Curtis Blaydes def. Rizvan Kuniev | Decision (split) (28–29, 29–28, 29–28) | 3 | 5:00 |
| 2024-07-27 | UFC 304: Edwards vs. Muhammad 2 | Heavyweight | Tom Aspinall def. Curtis Blaydes title | KO (punches) | 1 | 1:00 |
| 2024-03-09 | UFC 299: O'Malley vs. Vera 2 | Heavyweight | Curtis Blaydes def. Jailton Almeida | KO (punches) | 2 | 0:36 |
| 2023-04-22 | UFC Fight Night: Pavlovich vs. Blaydes | Heavyweight | Sergei Pavlovich def. Curtis Blaydes | TKO (punches) | 1 | 3:08 |
| 2022-07-23 | UFC Fight Night: Blaydes vs. Aspinall | Heavyweight | Curtis Blaydes def. Tom Aspinall | TKO (knee injury) | 1 | 0:15 |
| 2022-03-26 | UFC on ESPN: Blaydes vs. Daukaus | Heavyweight | Curtis Blaydes def. Chris Daukaus | TKO (punches) | 2 | 0:17 |
| 2021-09-25 | UFC 266: Volkanovski vs. Ortega | Heavyweight | Curtis Blaydes def. Jairzinho Rozenstruik | Decision (unanimous) (30–27, 30–27, 30–27) | 3 | 5:00 |
| 2021-02-20 | UFC Fight Night: Blaydes vs. Lewis | Heavyweight | Derrick Lewis def. Curtis Blaydes | KO (punch) | 2 | 1:26 |
| 2020-06-20 | UFC on ESPN: Blaydes vs. Volkov | Heavyweight | Curtis Blaydes def. Alexander Volkov | Decision (unanimous) (49–46, 48–47, 48–46) | 5 | 5:00 |
| 2020-01-25 | UFC Fight Night: Blaydes vs. dos Santos | Heavyweight | Curtis Blaydes def. Junior dos Santos | TKO (punches) | 2 | 1:06 |
| 2019-09-07 | UFC 242: Khabib vs. Poirier | Heavyweight | Curtis Blaydes def. Shamil Abdurakhimov | TKO (elbow and punches) | 2 | 2:22 |
| 2019-03-23 | UFC Fight Night: Thompson vs. Pettis | Heavyweight | Curtis Blaydes def. Justin Willis | Decision (unanimous) (30–27, 30–26, 30–25) | 3 | 5:00 |
| 2018-11-24 | UFC Fight Night: Blaydes vs. Ngannou 2 | Heavyweight | Francis Ngannou def. Curtis Blaydes | TKO (punches) | 1 | 0:45 |
| 2018-06-09 | UFC 225: Whittaker vs. Romero 2 | Heavyweight | Curtis Blaydes def. Alistair Overeem | TKO (elbows) | 3 | 2:56 |
| 2018-02-11 | UFC 221: Romero vs. Rockhold | Heavyweight | Curtis Blaydes def. Mark Hunt | Decision (unanimous) (30–26, 30–26, 29–27) | 3 | 5:00 |
| 2017-11-04 | UFC 217: Bisping vs. St-Pierre | Heavyweight | Curtis Blaydes def. Aleksei Oleinik | TKO (doctor stoppage) | 2 | 1:56 |
| 2017-07-08 | UFC 213: Romero vs. Whittaker | Heavyweight | Curtis Blaydes def. Daniel Omielańczuk | Decision (unanimous) (30–27, 30–27, 30–27) | 3 | 5:00 |
| 2017-02-04 | UFC Fight Night: Bermudez vs. The Korean Zombie | Heavyweight | Curtis Blaydes vs. Adam Milstead | No Contest (overturned) | 2 | 0:59 |
| 2016-10-01 | UFC Fight Night: Lineker vs. Dodson | Heavyweight | Curtis Blaydes def. Cody East | TKO (elbows) | 2 | 2:02 |
| 2016-04-10 | UFC Fight Night: Rothwell vs. dos Santos | Heavyweight | Francis Ngannou def. Curtis Blaydes | TKO (doctor stoppage) | 2 | 5:00 |