| 2026-08-15 | UFC 330: Makhachev vs. Machado Garry | Women’s Strawweight | Mackenzie Dern def. Gillian Robertson title | Decision (unanimous) (49–46, 49–46, 48–47) | 5 | 5:00 |
| 2025-10-25 | UFC 321: Aspinall vs. Gane | Women’s Strawweight | Mackenzie Dern def. Virna Jandiroba title | Decision (unanimous) (48–47, 48–47, 49–46) | 5 | 5:00 |
| 2025-01-11 | UFC Fight Night: Dern vs. Ribas 2 | Women’s Strawweight | Mackenzie Dern def. Amanda Ribas | Submission (armbar) | 3 | 4:56 |
| 2024-08-03 | UFC on ABC: Sandhagen vs. Nurmagomedov | Women’s Strawweight | Mackenzie Dern def. Lupita Godinez | Decision (unanimous) (29–28, 29–28, 29–28) | 3 | 5:00 |
| 2024-02-17 | UFC 298: Volkanovski vs. Topuria | Women’s Strawweight | Amanda Lemos def. Mackenzie Dern | Decision (unanimous) (29–28, 29–28, 29–28) | 3 | 5:00 |
| 2023-11-11 | UFC 295: Procházka vs. Pereira | Women’s Strawweight | Jéssica Andrade def. Mackenzie Dern | TKO (punches) | 2 | 3:15 |
| 2023-05-20 | UFC Fight Night: Dern vs. Hill | Women’s Strawweight | Mackenzie Dern def. Angela Hill | Decision (unanimous) (49–43, 49–44, 49–44) | 5 | 5:00 |
| 2022-10-01 | UFC Fight Night: Dern vs. Yan | Women’s Strawweight | Yan Xiaonan def. Mackenzie Dern | Decision (majority) (48–47, 48–47, 47–47) | 5 | 5:00 |
| 2022-04-09 | UFC 273: Volkanovski vs. The Korean Zombie | Women’s Strawweight | Mackenzie Dern def. Tecia Torres | Decision (split) (28–29, 29–28, 29–28) | 3 | 5:00 |
| 2021-10-09 | UFC Fight Night: Dern vs. Rodriguez | Women’s Strawweight | Marina Rodriguez def. Mackenzie Dern | Decision (unanimous) (49–46, 49–46, 49–46) | 5 | 5:00 |
| 2021-04-10 | UFC on ABC: Vettori vs. Holland | Women’s Strawweight | Mackenzie Dern def. Nina Ansaroff | Submission (armbar) | 1 | 4:48 |
| 2020-12-12 | UFC 256: Figueiredo vs. Moreno | Women’s Strawweight | Mackenzie Dern def. Virna Jandiroba | Decision (unanimous) (29–28, 29–28, 29–28) | 3 | 5:00 |
| 2020-09-19 | UFC Fight Night: Covington vs. Woodley | Women’s Strawweight | Mackenzie Dern def. Randa Markos | Submission (armbar) | 1 | 3:44 |
| 2020-05-30 | UFC on ESPN: Woodley vs. Burns | Women’s Strawweight | Mackenzie Dern def. Hannah Cifers | Submission (kneebar) | 1 | 2:36 |
| 2019-10-12 | UFC Fight Night: Joanna vs. Waterson | Women’s Strawweight | Amanda Ribas def. Mackenzie Dern | Decision (unanimous) (30–27, 30–27, 30–27) | 3 | 5:00 |
| 2018-05-12 | UFC 224: Nunes vs. Pennington | Catchweight | Mackenzie Dern def. Amanda Cooper | Submission (rear naked choke) | 1 | 2:27 |
| 2018-03-03 | UFC 222: Cyborg vs. Kunitskaya | Women’s Strawweight | Mackenzie Dern def. Ashley Yoder | Decision (split) (28–29, 29–28, 29–28) | 3 | 5:00 |