| 2025-11-15 | UFC 322: Della Maddalena vs. Makhachev | Welterweight | Carlos Prates def. Leon Edwards | KO (punches) | 2 | 1:28 |
| 2025-03-22 | UFC Fight Night: Edwards vs. Brady | Welterweight | Sean Brady def. Leon Edwards | Submission (guillotine choke) | 4 | 1:39 |
| 2024-07-27 | UFC 304: Edwards vs. Muhammad 2 | Welterweight | Belal Muhammad def. Leon Edwards title | Decision (unanimous) (48–47, 48–47, 49–46) | 5 | 5:00 |
| 2023-12-16 | UFC 296: Edwards vs. Covington | Welterweight | Leon Edwards def. Colby Covington title | Decision (unanimous) (49–46, 49–46, 49–46) | 5 | 5:00 |
| 2023-03-18 | UFC 286: Edwards vs. Usman 3 | Welterweight | Leon Edwards def. Kamaru Usman title | Decision (majority) (48–46, 48–46, 47–47) | 5 | 5:00 |
| 2022-08-20 | UFC 278: Usman vs. Edwards 2 | Welterweight | Leon Edwards def. Kamaru Usman title | KO (head kick) | 5 | 4:04 |
| 2021-06-12 | UFC 263: Adesanya vs. Vettori 2 | Welterweight | Leon Edwards def. Nate Diaz | Decision (unanimous) (49–46, 49–46, 49–46) | 5 | 5:00 |
| 2021-03-13 | UFC Fight Night: Edwards vs. Muhammad | Welterweight | Leon Edwards vs. Belal Muhammad | No Contest (accidental eye poke) | 2 | 0:18 |
| 2019-07-20 | UFC on ESPN: dos Anjos vs. Edwards | Welterweight | Leon Edwards def. Rafael dos Anjos | Decision (unanimous) (50–45, 49–46, 49–46) | 5 | 5:00 |
| 2019-03-16 | UFC Fight Night: Till vs. Masvidal | Welterweight | Leon Edwards def. Gunnar Nelson | Decision (split) (29–27, 29–28, 28–29) | 3 | 5:00 |
| 2018-06-23 | UFC Fight Night: Cowboy vs. Edwards | Welterweight | Leon Edwards def. Donald Cerrone | Decision (unanimous) (48–47, 48–47, 48–47) | 5 | 5:00 |
| 2018-03-17 | UFC Fight Night: Werdum vs. Volkov | Welterweight | Leon Edwards def. Peter Sobotta | TKO (punches) | 3 | 4:59 |
| 2017-09-02 | UFC Fight Night: Volkov vs. Struve | Welterweight | Leon Edwards def. Bryan Barberena | Decision (unanimous) (29–28, 29–28, 29–28) | 3 | 5:00 |
| 2017-03-18 | UFC Fight Night: Manuwa vs. Anderson | Welterweight | Leon Edwards def. Vicente Luque | Decision (unanimous) (29–28, 29–28, 29–28) | 3 | 5:00 |
| 2016-10-08 | UFC 204: Bisping vs. Henderson 2 | Welterweight | Leon Edwards def. Albert Tumenov | Submission (rear-naked choke) | 3 | 3:01 |
| 2016-05-08 | UFC Fight Night: Overeem vs. Arlovski | Welterweight | Leon Edwards def. Dominic Waters | Decision (unanimous) (30–27, 30–27, 30–27) | 3 | 5:00 |
| 2015-12-19 | UFC on Fox: dos Anjos vs. Cowboy 2 | Welterweight | Kamaru Usman def. Leon Edwards | Decision (unanimous) (29–28, 30–27, 29–28) | 3 | 5:00 |
| 2015-07-18 | UFC Fight Night: Bisping vs. Leites | Welterweight | Leon Edwards def. Pawel Pawlak | Decision (unanimous) (30–27, 30–27, 30–27) | 3 | 5:00 |
| 2015-04-11 | UFC Fight Night: Gonzaga vs. Cro Cop 2 | Welterweight | Leon Edwards def. Seth Baczynski | KO (punches) | 1 | 0:08 |
| 2014-11-08 | UFC Fight Night: Shogun vs. Saint Preux | Welterweight | Cláudio Silva def. Leon Edwards | Decision (split) (28–29, 29–28, 29–28) | 3 | 5:00 |