| 2025-08-23 | UFC Fight Night: Walker vs. Zhang | Catchweight | Aljamain Sterling def. Brian Ortega | Decision (unanimous) (50–45, 50–45, 50–45) | 5 | 5:00 |
| 2024-09-14 | UFC 306: O'Malley vs. Dvalishvili | Featherweight | Diego Lopes def. Brian Ortega | Decision (unanimous) (30–26, 30–27, 30–27) | 3 | 5:00 |
| 2024-02-24 | UFC Fight Night: Moreno vs. Royval 2 | Featherweight | Brian Ortega def. Yair Rodríguez | Submission (arm-triangle choke) | 3 | 0:58 |
| 2022-07-16 | UFC on ABC: Ortega vs. Rodríguez | Featherweight | Yair Rodríguez def. Brian Ortega | TKO (shoulder injury) | 1 | 4:11 |
| 2021-09-25 | UFC 266: Volkanovski vs. Ortega | Featherweight | Alexander Volkanovski def. Brian Ortega title | Decision (unanimous) (49–46, 50–45, 50–44) | 5 | 5:00 |
| 2020-10-18 | UFC Fight Night: Ortega vs. The Korean Zombie | Featherweight | Brian Ortega def. Chan Sung Jung | Decision (unanimous) (50–45, 50–45, 50–45) | 5 | 5:00 |
| 2018-12-08 | UFC 231: Holloway vs. Ortega | Featherweight | Max Holloway def. Brian Ortega title | TKO (doctor stoppage) | 4 | 5:00 |
| 2018-03-03 | UFC 222: Cyborg vs. Kunitskaya | Featherweight | Brian Ortega def. Frankie Edgar | KO (punch) | 1 | 4:44 |
| 2017-12-09 | UFC Fight Night: Swanson vs. Ortega | Featherweight | Brian Ortega def. Cub Swanson | Submission (guillotine choke) | 2 | 3:22 |
| 2017-07-29 | UFC 214: Cormier vs. Jones 2 | Featherweight | Brian Ortega def. Renato Moicano | Submission (guillotine choke) | 3 | 2:59 |
| 2016-06-04 | UFC 199: Rockhold vs. Bisping 2 | Featherweight | Brian Ortega def. Clay Guida | KO (knee) | 3 | 4:40 |
| 2016-01-02 | UFC 195: Lawler vs. Condit | Featherweight | Brian Ortega def. Diego Brandao | Submission (triangle choke) | 3 | 1:37 |
| 2015-06-06 | UFC Fight Night: Boetsch vs. Henderson | Featherweight | Brian Ortega def. Thiago Tavares | TKO (punches) | 3 | 4:10 |
| 2014-07-26 | UFC on Fox: Lawler vs. Brown | Featherweight | Brian Ortega vs. Mike De La Torre | No contest (overturned; original: No Contest (overturned)) | 1 | 1:39 |