| 2022-01-22 | UFC 270: Ngannou vs. Gane | Heavyweight | Francis Ngannou def. Ciryl Gane title | Decision (unanimous) (48–47, 48–47, 49–46) | 5 | 5:00 |
| 2021-03-27 | UFC 260: Miocic vs. Ngannou 2 | Heavyweight | Francis Ngannou def. Stipe Miocic title | KO (punch) | 2 | 0:52 |
| 2020-05-09 | UFC 249: Ferguson vs. Gaethje | Heavyweight | Francis Ngannou def. Jairzinho Rozenstruik | KO (punches) | 1 | 0:20 |
| 2019-06-29 | UFC on ESPN: Ngannou vs. dos Santos | Heavyweight | Francis Ngannou def. Junior dos Santos | TKO (punches) | 1 | 1:11 |
| 2019-02-17 | UFC on ESPN: Ngannou vs. Velasquez | Heavyweight | Francis Ngannou def. Cain Velasquez | KO (punches) | 1 | 0:26 |
| 2018-11-24 | UFC Fight Night: Blaydes vs. Ngannou 2 | Heavyweight | Francis Ngannou def. Curtis Blaydes | TKO (punches) | 1 | 0:45 |
| 2018-07-07 | UFC 226: Miocic vs. Cormier | Heavyweight | Derrick Lewis def. Francis Ngannou | Decision (unanimous) (29–28, 29–28, 30–27) | 3 | 5:00 |
| 2018-01-20 | UFC 220: Miocic vs. Ngannou | Heavyweight | Stipe Miocic def. Francis Ngannou title | Decision (unanimous) (50–44, 50–44, 50–44) | 5 | 5:00 |
| 2017-12-02 | UFC 218: Holloway vs. Aldo 2 | Heavyweight | Francis Ngannou def. Alistair Overeem | KO (punch) | 1 | 1:42 |
| 2017-01-28 | UFC on Fox: Shevchenko vs. Peña | Heavyweight | Francis Ngannou def. Andrei Arlovski | TKO (punches) | 1 | 1:32 |
| 2016-12-09 | UFC Fight Night: Lewis vs. Abdurakhimov | Heavyweight | Francis Ngannou def. Anthony Hamilton | Submission (kimura) | 1 | 1:57 |
| 2016-07-23 | UFC on Fox: Holm vs. Shevchenko | Heavyweight | Francis Ngannou def. Bojan Mihajlović | TKO (punches) | 1 | 1:34 |
| 2016-04-10 | UFC Fight Night: Rothwell vs. dos Santos | Heavyweight | Francis Ngannou def. Curtis Blaydes | TKO (doctor stoppage) | 2 | 5:00 |
| 2015-12-19 | UFC on Fox: dos Anjos vs. Cowboy 2 | Heavyweight | Francis Ngannou def. Luis Henrique | KO (punch) | 2 | 2:53 |