| 2024-12-07 | UFC 310: Pantoja vs. Asakura | Lightweight | Chase Hooper def. Clay Guida | Submission (armbar) | 1 | 3:41 |
| 2023-12-02 | UFC on ESPN: Dariush vs. Tsarukyan | Lightweight | Joaquim Silva def. Clay Guida | Decision (unanimous) (29–28, 29–28, 29–28) | 3 | 5:00 |
| 2023-04-15 | UFC on ESPN: Holloway vs. Allen | Lightweight | Rafa García def. Clay Guida | Decision (unanimous) (30–27, 30–27, 30–27) | 3 | 5:00 |
| 2022-12-03 | UFC on ESPN: Thompson vs. Holland | Lightweight | Clay Guida def. Scott Holtzman | Decision (split) (28–29, 29–28, 29–28) | 3 | 5:00 |
| 2022-04-23 | UFC Fight Night: Lemos vs. Andrade | Lightweight | Claudio Puelles def. Clay Guida | Submission (kneebar) | 1 | 3:01 |
| 2021-12-04 | UFC on ESPN: Font vs. Aldo | Lightweight | Clay Guida def. Leonardo Santos | Submission (rear-naked choke) | 2 | 1:21 |
| 2021-08-21 | UFC on ESPN: Cannonier vs. Gastelum | Lightweight | Mark Madsen def. Clay Guida | Decision (split) (29–28, 28–29, 30–27) | 3 | 5:00 |
| 2021-02-06 | UFC Fight Night: Overeem vs. Volkov | Lightweight | Clay Guida def. Michael Johnson | Decision (unanimous) (30–27, 30–27, 30–27) | 3 | 5:00 |
| 2020-06-20 | UFC on ESPN: Blaydes vs. Volkov | Lightweight | Bobby Green def. Clay Guida | Decision (unanimous) (29–28, 29–28, 30–27) | 3 | 5:00 |
| 2019-08-03 | UFC on ESPN: Covington vs. Lawler | Lightweight | Jim Miller def. Clay Guida | Technical Submission (guillotine choke) | 1 | 0:58 |
| 2019-05-11 | UFC 237: Namajunas vs. Andrade | Lightweight | Clay Guida def. B.J. Penn | Decision (unanimous) (29–28, 29–28, 29–27) | 3 | 5:00 |
| 2018-06-09 | UFC 225: Whittaker vs. Romero 2 | Lightweight | Charles Oliveira def. Clay Guida | Submission (guillotine choke) | 1 | 2:18 |
| 2017-11-11 | UFC Fight Night: Poirier vs. Pettis | Lightweight | Clay Guida def. Joe Lauzon | TKO (punches and elbows) | 1 | 1:07 |
| 2017-06-25 | UFC Fight Night: Chiesa vs. Lee | Lightweight | Clay Guida def. Erik Koch | Decision (unanimous) (29–28, 29–26, 30–26) | 3 | 5:00 |
| 2016-06-04 | UFC 199: Rockhold vs. Bisping 2 | Featherweight | Brian Ortega def. Clay Guida | KO (knee) | 3 | 4:40 |
| 2015-11-07 | UFC Fight Night: Belfort vs. Henderson 3 | Featherweight | Thiago Tavares def. Clay Guida | Submission (guillotine choke) | 1 | 0:39 |
| 2015-04-04 | UFC Fight Night: Mendes vs. Lamas | Featherweight | Clay Guida def. Robbie Peralta | Decision (unanimous) (30–27, 30–27, 30–27) | 3 | 5:00 |
| 2014-07-26 | UFC on Fox: Lawler vs. Brown | Featherweight | Dennis Bermudez def. Clay Guida | Submission (rear-naked choke) | 2 | 2:57 |
| 2014-04-11 | UFC Fight Night: Nogueira vs. Nelson | Featherweight | Clay Guida def. Tatsuya Kawajiri | Decision (unanimous) (30–27, 30–27, 30–27) | 3 | 5:00 |
| 2013-08-31 | UFC 164: Henderson vs. Pettis 2 | Featherweight | Chad Mendes def. Clay Guida | TKO (punches) | 3 | 0:30 |
| 2013-01-26 | UFC on Fox: Johnson vs. Dodson | Featherweight | Clay Guida def. Hatsu Hioki | Decision (split) (28–29, 30–27, 29–28) | 3 | 5:00 |
| 2012-06-22 | UFC on FX: Maynard vs. Guida | Lightweight | Gray Maynard def. Clay Guida | Decision (split) (48–47, 47–48, 48–47) | 5 | 5:00 |
| 2011-11-12 | UFC on Fox: Velasquez vs. dos Santos | Lightweight | Benson Henderson def. Clay Guida | Decision (unanimous) (29–28, 30–27, 30–27) | 3 | 5:00 |
| 2011-06-04 | The Ultimate Fighter: Team Lesnar vs. Team dos Santos Finale | Lightweight | Clay Guida def. Anthony Pettis | Decision (unanimous) (30–27, 30–27, 30–27) | 3 | 5:00 |
| 2011-01-01 | UFC 125: Resolution | Lightweight | Clay Guida def. Takanori Gomi | Submission (guillotine choke) | 2 | 4:27 |
| 2010-08-07 | UFC 117: Silva vs. Sonnen | Lightweight | Clay Guida def. Rafael dos Anjos | TKO (jaw injury) | 3 | 1:51 |
| 2010-03-21 | UFC Live: Vera vs. Jones | Lightweight | Clay Guida def. Shannon Gugerty | Submission (arm-triangle choke) | 2 | 3:40 |
| 2009-12-12 | UFC 107: Penn vs. Sanchez | Lightweight | Kenny Florian def. Clay Guida | Submission (rear-naked choke) | 2 | 2:19 |
| 2009-06-20 | The Ultimate Fighter: United States vs. United Kingdom Finale | Lightweight | Diego Sanchez def. Clay Guida | Decision (split) (28–29, 29–27, 29–28) | 3 | 5:00 |
| 2009-01-31 | UFC 94: St-Pierre vs. Penn 2 | Lightweight | Clay Guida def. Nate Diaz | Decision (split) (29–28, 28–29, 29–28) | 3 | 5:00 |
| 2008-09-17 | UFC Fight Night: Diaz vs. Neer | Lightweight | Clay Guida def. Mac Danzig | Decision (unanimous) (30–27, 29–28, 29–28) | 3 | 5:00 |
| 2008-04-02 | UFC Fight Night: Florian vs. Lauzon | Lightweight | Clay Guida def. Samy Schiavo | TKO (punches) | 1 | 4:15 |
| 2007-12-08 | The Ultimate Fighter: Team Hughes vs. Team Serra Finale | Lightweight | Roger Huerta def. Clay Guida | Submission (rear-naked choke) | 3 | 0:51 |
| 2007-08-25 | UFC 74: Respect | Lightweight | Clay Guida def. Marcus Aurélio | Decision (split) (30–27, 28–29, 30–27) | 3 | 5:00 |
| 2007-06-16 | UFC 72: Victory | Lightweight | Tyson Griffin def. Clay Guida | Decision (split) (29–28, 28–29, 29–28) | 3 | 5:00 |
| 2007-01-25 | UFC Fight Night: Evans vs. Salmon | Lightweight | Din Thomas def. Clay Guida | Decision (unanimous) (29–28, 29–28, 29–28) | 3 | 5:00 |
| 2006-10-14 | UFC 64: Unstoppable | Lightweight | Clay Guida def. Justin James | Submission (rear-naked choke) | 2 | 4:42 |