| 2011-10-29 | UFC 137: Penn vs. Diaz | Catchweight | Bart Palaszewski def. Tyson Griffin | KO (punches) | 1 | 2:45 |
| 2011-06-26 | UFC Live: Kongo vs. Barry | Featherweight | Tyson Griffin def. Manny Gamburyan | Decision (majority) (29–28, 29–28, 29–29) | 3 | 5:00 |
| 2010-11-20 | UFC 123: Rampage vs. Machida | Lightweight | Nik Lentz def. Tyson Griffin | Decision (split) (29–28, 27–30, 29–28) | 3 | 5:00 |
| 2010-08-01 | UFC Live: Jones vs. Matyushenko | Lightweight | Takanori Gomi def. Tyson Griffin | KO (punch) | 1 | 1:04 |
| 2010-06-12 | UFC 115: Liddell vs. Franklin | Lightweight | Evan Dunham def. Tyson Griffin | Decision (split) (30–27, 28–29, 29–28) | 3 | 5:00 |
| 2009-09-19 | UFC 103: Franklin vs. Belfort | Catchweight | Tyson Griffin def. Hermes França | KO (punches) | 2 | 3:26 |
| 2009-04-01 | UFC Fight Night: Condit vs. Kampmann | Lightweight | Tyson Griffin def. Rafael dos Anjos | Decision (unanimous) (30–27, 30–27, 30–27) | 3 | 5:00 |
| 2008-10-25 | UFC 90: Silva vs. Côté | Lightweight | Sean Sherk def. Tyson Griffin | Decision (unanimous) (30–27, 29–28, 29–28) | 3 | 5:00 |
| 2008-07-05 | UFC 86: Jackson vs. Griffin | Lightweight | Tyson Griffin def. Marcus Aurélio | Decision (unanimous) | 3 | 5:00 |
| 2008-02-02 | UFC 81: Breaking Point | Lightweight | Tyson Griffin def. Gleison Tibau | Decision (unanimous) (30–27, 30–27, 30–27) | 3 | 5:00 |
| 2007-09-22 | UFC 76: Knockout | Lightweight | Tyson Griffin def. Thiago Tavares | Decision (unanimous) (29–28, 30–27, 29–28) | 3 | 5:00 |
| 2007-06-16 | UFC 72: Victory | Lightweight | Tyson Griffin def. Clay Guida | Decision (split) (29–28, 28–29, 29–28) | 3 | 5:00 |
| 2007-02-03 | UFC 67: All or Nothing | Lightweight | Frankie Edgar def. Tyson Griffin | Decision (unanimous) (29–28, 29–28, 30–27) | 3 | 5:00 |
| 2006-09-23 | UFC 63: Hughes vs. Penn | Lightweight | Tyson Griffin def. David Lee | Submission (rear-naked choke) | 1 | 1:50 |