| 2022-12-03 | UFC on ESPN: Thompson vs. Holland | Lightweight | Clay Guida def. Scott Holtzman | Decision (split) (28–29, 29–28, 29–28) | 3 | 5:00 |
| 2021-04-10 | UFC on ABC: Vettori vs. Holland | Lightweight | Mateusz Gamrot def. Scott Holtzman | KO (punches) | 2 | 1:22 |
| 2020-08-08 | UFC Fight Night: Lewis vs. Oleinik | Catchweight | Beneil Dariush def. Scott Holtzman | KO (spinning backfist) | 1 | 4:38 |
| 2020-02-15 | UFC Fight Night: Anderson vs. Błachowicz 2 | Lightweight | Scott Holtzman def. Jim Miller | Decision (unanimous) (30–27, 29–28, 29–28) | 3 | 5:00 |
| 2019-08-03 | UFC on ESPN: Covington vs. Lawler | Catchweight | Scott Holtzman def. Dong Hyun Ma | TKO (doctor stoppage) | 2 | 5:00 |
| 2019-02-17 | UFC on ESPN: Ngannou vs. Velasquez | Lightweight | Nik Lentz def. Scott Holtzman | Decision (unanimous) (29–28, 29–28, 29–28) | 3 | 5:00 |
| 2018-10-06 | UFC 229: Khabib vs. McGregor | Lightweight | Scott Holtzman def. Alan Patrick | KO (elbows) | 3 | 3:42 |
| 2017-12-09 | UFC Fight Night: Swanson vs. Ortega | Lightweight | Scott Holtzman def. Darrell Horcher | Decision (unanimous) (30–27, 30–27, 30–27) | 3 | 5:00 |
| 2017-04-22 | UFC Fight Night: Swanson vs. Lobov | Lightweight | Scott Holtzman def. Michael McBride | Decision (unanimous) (30–27, 30–27, 30–26) | 3 | 5:00 |
| 2016-12-17 | UFC on Fox: VanZant vs. Waterson | Lightweight | Josh Emmett def. Scott Holtzman | Decision (unanimous) (29–28, 29–28, 29–28) | 3 | 5:00 |
| 2016-07-13 | UFC Fight Night: McDonald vs. Lineker | Lightweight | Scott Holtzman def. Cody Pfister | Decision (unanimous) (30–27, 30–27, 29–28) | 3 | 5:00 |
| 2016-01-02 | UFC 195: Lawler vs. Condit | Lightweight | Drew Dober def. Scott Holtzman | Decision (unanimous) (29–28, 29–28, 29–28) | 3 | 5:00 |
| 2015-08-08 | UFC Fight Night: Teixeira vs. Saint Preux | Lightweight | Scott Holtzman def. Anthony Christodoulou | Submission (rear-naked choke) | 3 | 2:40 |