| 2019-10-18 | UFC on ESPN: Reyes vs. Weidman | Lightweight | Joe Lauzon def. Jonathan Pearce | TKO (punches) | 1 | 1:33 |
| 2018-04-07 | UFC 223: Khabib vs. Iaquinta | Lightweight | Chris Gruetzemacher def. Joe Lauzon | TKO (corner stoppage) | 2 | 5:00 |
| 2017-11-11 | UFC Fight Night: Poirier vs. Pettis | Lightweight | Clay Guida def. Joe Lauzon | TKO (punches and elbows) | 1 | 1:07 |
| 2017-04-22 | UFC Fight Night: Swanson vs. Lobov | Lightweight | Stevie Ray def. Joe Lauzon | Decision (majority) (28–27, 29–27, 28–28) | 3 | 5:00 |
| 2017-01-15 | UFC Fight Night: Rodríguez vs. Penn | Lightweight | Joe Lauzon def. Marcin Held | Decision (split) (27–30, 29–28, 29–28) | 3 | 5:00 |
| 2016-08-27 | UFC on Fox: Maia vs. Condit | Lightweight | Jim Miller def. Joe Lauzon | Decision (split) (29–28, 28–29, 29–28) | 3 | 5:00 |
| 2016-07-09 | UFC 200: Tate vs. Nunes | Lightweight | Joe Lauzon def. Diego Sanchez | TKO (punches) | 1 | 1:26 |
| 2015-12-11 | The Ultimate Fighter: Team McGregor vs. Team Faber Finale | Lightweight | Evan Dunham def. Joe Lauzon | Decision (unanimous) (30–26, 30–27, 30–26) | 3 | 5:00 |
| 2015-07-25 | UFC on Fox: Dillashaw vs. Barão 2 | Lightweight | Joe Lauzon def. Takanori Gomi | TKO (punches) | 1 | 2:37 |
| 2015-01-31 | UFC 183: Silva vs. Diaz | Lightweight | Al Iaquinta def. Joe Lauzon | TKO (punches) | 2 | 3:34 |
| 2014-09-05 | UFC Fight Night: Jacaré vs. Mousasi | Lightweight | Joe Lauzon def. Michael Chiesa | TKO (doctor stoppage) | 2 | 2:14 |
| 2013-12-14 | UFC on Fox: Johnson vs. Benavidez 2 | Lightweight | Joe Lauzon def. Mac Danzig | Decision (unanimous) (30–27, 30–27, 30–27) | 3 | 5:00 |
| 2013-08-17 | UFC Fight Night: Shogun vs. Sonnen | Lightweight | Michael Johnson def. Joe Lauzon | Decision (unanimous) (30–27, 30–27, 30–25) | 3 | 5:00 |
| 2012-12-29 | UFC 155: dos Santos vs. Velasquez 2 | Lightweight | Jim Miller def. Joe Lauzon | Decision (unanimous) (29–28, 29–28, 29–28) | 3 | 5:00 |
| 2012-08-04 | UFC on Fox: Shogun vs. Vera | Lightweight | Joe Lauzon def. Jamie Varner | Submission (triangle choke) | 3 | 2:44 |
| 2012-02-26 | UFC 144: Edgar vs. Henderson | Lightweight | Anthony Pettis def. Joe Lauzon | KO (head kick and punches) | 1 | 1:21 |
| 2011-10-08 | UFC 136: Edgar vs. Maynard III | Lightweight | Joe Lauzon def. Melvin Guillard | Submission (rear-naked choke) | 1 | 0:47 |
| 2011-06-26 | UFC Live: Kongo vs. Barry | Lightweight | Joe Lauzon def. Curt Warburton | Submission (kimura) | 1 | 1:58 |
| 2010-11-20 | UFC 123: Rampage vs. Machida | Lightweight | George Sotiropoulos def. Joe Lauzon | Submission (kimura) | 2 | 2:43 |
| 2010-08-28 | UFC 118: Edgar vs. Penn 2 | Lightweight | Joe Lauzon def. Gabe Ruediger | Submission (armbar) | 1 | 2:01 |
| 2010-01-02 | UFC 108: Evans vs. Silva | Lightweight | Sam Stout def. Joe Lauzon | Decision (unanimous) (30–26, 30–27, 30–27) | 3 | 5:00 |
| 2009-02-07 | UFC Fight Night: Lauzon vs. Stephens | Lightweight | Joe Lauzon def. Jeremy Stephens | Submission (armbar) | 2 | 4:43 |
| 2008-09-17 | UFC Fight Night: Diaz vs. Neer | Lightweight | Joe Lauzon def. Kyle Bradley | TKO (punches) | 2 | 1:34 |
| 2008-04-02 | UFC Fight Night: Florian vs. Lauzon | Lightweight | Kenny Florian def. Joe Lauzon | TKO (punches) | 2 | 3:28 |
| 2007-11-17 | UFC 78: Validation | Lightweight | Joe Lauzon def. Jason Reinhardt | Submission (rear-naked choke) | 1 | 1:14 |
| 2007-06-23 | The Ultimate Fighter: Team Pulver vs. Team Penn Finale | Lightweight | Joe Lauzon def. Brandon Melendez | Submission (triangle choke) | 2 | 2:09 |
| 2006-09-23 | UFC 63: Hughes vs. Penn | Lightweight | Joe Lauzon def. Jens Pulver | KO (punch) | 1 | 0:48 |