| 2020-09-27 | UFC 253: Adesanya vs. Costa | Welterweight | Jake Matthews def. Diego Sanchez | Decision (unanimous) (30–26, 30–26, 30–26) | 3 | 5:00 |
| 2020-02-15 | UFC Fight Night: Anderson vs. Błachowicz 2 | Welterweight | Diego Sanchez def. Michel Pereira | DQ (illegal knee) | 3 | 3:09 |
| 2019-07-06 | UFC 239: Jones vs. Santos | Welterweight | Michael Chiesa def. Diego Sanchez | Decision (unanimous) (30–26, 30–26, 30–26) | 3 | 5:00 |
| 2019-03-02 | UFC 235: Jones vs. Smith | Welterweight | Diego Sanchez def. Mickey Gall | TKO (punches) | 2 | 4:13 |
| 2018-09-08 | UFC 228: Woodley vs. Till | Welterweight | Diego Sanchez def. Craig White | Decision (unanimous) (30–27, 30–27, 30–27) | 3 | 5:00 |
| 2017-11-11 | UFC Fight Night: Poirier vs. Pettis | Welterweight | Matt Brown def. Diego Sanchez | KO (elbow) | 1 | 3:44 |
| 2017-04-22 | UFC Fight Night: Swanson vs. Lobov | Lightweight | Al Iaquinta def. Diego Sanchez | KO (punches) | 1 | 1:38 |
| 2016-11-05 | The Ultimate Fighter Latin America 3 Finale: dos Anjos vs. Ferguson | Lightweight | Diego Sanchez def. Marcin Held | Decision (unanimous) (29–28, 29–28, 29–27) | 3 | 5:00 |
| 2016-07-09 | UFC 200: Tate vs. Nunes | Lightweight | Joe Lauzon def. Diego Sanchez | TKO (punches) | 1 | 1:26 |
| 2016-03-05 | UFC 196: McGregor vs. Diaz | Lightweight | Diego Sanchez def. Jim Miller | Decision (unanimous) (29–28, 29–28, 29–28) | 3 | 5:00 |
| 2015-11-21 | The Ultimate Fighter Latin America 2 Finale: Magny vs. Gastelum | Featherweight | Ricardo Lamas def. Diego Sanchez | Decision (unanimous) (30–27, 30–27, 30–27) | 3 | 5:00 |
| 2014-06-07 | UFC Fight Night: Henderson vs. Khabilov | Lightweight | Diego Sanchez def. Ross Pearson | Decision (split) (27–30, 30–27, 29–28) | 3 | 5:00 |
| 2014-03-15 | UFC 171: Hendricks vs. Lawler | Lightweight | Myles Jury def. Diego Sanchez | Decision (unanimous) (30–27, 30–27, 29–28) | 3 | 5:00 |
| 2013-10-19 | UFC 166: Velasquez vs. dos Santos III | Lightweight | Gilbert Melendez def. Diego Sanchez | Decision (unanimous) (29–28, 30–27, 29–28) | 3 | 5:00 |
| 2013-03-03 | UFC on Fuel TV: Silva vs. Stann | Catchweight | Diego Sanchez def. Takanori Gomi | Decision (split) (29–28, 28–29, 29–28) | 3 | 5:00 |
| 2012-02-15 | UFC on Fuel TV: Sanchez vs. Ellenberger | Welterweight | Jake Ellenberger def. Diego Sanchez | Decision (unanimous) (29–28, 29–28, 29–28) | 3 | 5:00 |
| 2011-03-03 | UFC Live: Sanchez vs. Kampmann | Welterweight | Diego Sanchez def. Martin Kampmann | Decision (unanimous) (29–28, 29–28, 29–28) | 3 | 5:00 |
| 2010-10-23 | UFC 121: Lesnar vs. Velasquez | Welterweight | Diego Sanchez def. Paulo Thiago | Decision (unanimous) (30–26, 29–28, 29–28) | 3 | 5:00 |
| 2010-05-29 | UFC 114: Rampage vs. Evans | Welterweight | John Hathaway def. Diego Sanchez | Decision (unanimous) (30–27, 30–27, 30–26) | 3 | 5:00 |
| 2009-12-12 | UFC 107: Penn vs. Sanchez | Lightweight | B.J. Penn def. Diego Sanchez title | TKO (doctor stoppage) | 5 | 2:37 |
| 2009-06-20 | The Ultimate Fighter: United States vs. United Kingdom Finale | Lightweight | Diego Sanchez def. Clay Guida | Decision (split) (28–29, 29–27, 29–28) | 3 | 5:00 |
| 2009-02-21 | UFC 95: Sanchez vs. Stevenson | Lightweight | Diego Sanchez def. Joe Stevenson | Decision (unanimous) (29–28, 30–27, 30–27) | 3 | 5:00 |
| 2008-06-21 | The Ultimate Fighter: Team Rampage vs. Team Forrest Finale | Welterweight | Diego Sanchez def. Luigi Fioravanti | TKO (punches) | 3 | 4:07 |
| 2008-03-01 | UFC 82: Pride of a Champion | Welterweight | Diego Sanchez def. David Bielkheden | TKO (submission to strikes) | 1 | 4:43 |
| 2007-09-22 | UFC 76: Knockout | Welterweight | Jon Fitch def. Diego Sanchez | Decision (split) (30–27, 28–29, 29–28) | 3 | 5:00 |
| 2007-04-07 | UFC 69: Shootout | Welterweight | Josh Koscheck def. Diego Sanchez | Decision (unanimous) (30–27, 30–27, 30–27) | 3 | 5:00 |
| 2006-12-13 | UFC Fight Night: Sanchez vs. Riggs | Welterweight | Diego Sanchez def. Joe Riggs | KO (knee and punches) | 1 | 1:45 |
| 2006-08-17 | UFC Fight Night 6 | Welterweight | Diego Sanchez def. Karo Parisyan | Decision (unanimous) (29–28, 29–28, 30–26) | 3 | 5:00 |
| 2006-05-27 | UFC 60: Hughes vs. Gracie | Welterweight | Diego Sanchez def. John Alessio | Decision (unanimous) (30–27, 29–28, 29–28) | 3 | 5:00 |
| 2005-11-05 | The Ultimate Fighter: Team Hughes vs. Team Franklin Finale | Welterweight | Diego Sanchez def. Nick Diaz | Decision (unanimous) (30–27, 30–27, 30–27) | 3 | 5:00 |
| 2005-08-20 | UFC 54: Boiling Point | Welterweight | Diego Sanchez def. Brian Gassaway | TKO (submission to punches) | 2 | 1:56 |
| 2005-04-09 | The Ultimate Fighter: Team Couture vs. Team Liddell Finale | Middleweight | Diego Sanchez def. Kenny Florian | TKO (punches) | 1 | 2:49 |