| 2011-09-24 | UFC 135: Jones vs. Rampage | Welterweight | Josh Koscheck def. Matt Hughes | KO (punches) | 1 | 4:59 |
| 2010-11-20 | UFC 123: Rampage vs. Machida | Welterweight | B.J. Penn def. Matt Hughes | KO (punches) | 1 | 0:21 |
| 2010-08-07 | UFC 117: Silva vs. Sonnen | Welterweight | Matt Hughes def. Ricardo Almeida | Technical Submission (Anaconda choke) | 1 | 3:15 |
| 2010-04-10 | UFC 112: Invincible | Welterweight | Matt Hughes def. Renzo Gracie | TKO (leg kicks and punches) | 3 | 4:40 |
| 2009-05-23 | UFC 98: Evans vs. Machida | Welterweight | Matt Hughes def. Matt Serra | Decision (unanimous) (29-28, 29-28, 29-28) | 3 | 5:00 |
| 2008-06-07 | UFC 85: Bedlam | Catchweight | Thiago Alves def. Matt Hughes | TKO (flying knee and punches) | 2 | 1:02 |
| 2007-12-29 | UFC 79: Nemesis | Welterweight | Georges St-Pierre def. Matt Hughes title | Submission (armbar) | 2 | 4:54 |
| 2007-03-03 | UFC 68: The Uprising | Welterweight | Matt Hughes def. Chris Lytle | Decision (unanimous) (30-27, 30-27, 30-27) | 3 | 5:00 |
| 2006-11-18 | UFC 65: Bad Intentions | Welterweight | Georges St-Pierre def. Matt Hughes title | TKO (head kick and punches) | 2 | 1:25 |
| 2006-09-23 | UFC 63: Hughes vs. Penn | Welterweight | Matt Hughes def. B.J. Penn title | TKO (punches) | 3 | 3:53 |
| 2006-05-27 | UFC 60: Hughes vs. Gracie | Catchweight | Matt Hughes def. Royce Gracie | TKO (punches) | 1 | 4:39 |
| 2005-11-19 | UFC 56: Full Force | Catchweight | Matt Hughes def. Joe Riggs | Submission (kimura) | 1 | 3:28 |
| 2005-04-16 | UFC 52: Couture vs. Liddell | Welterweight | Matt Hughes def. Frank Trigg title | Submission (rear-naked choke) | 1 | 4:05 |
| 2004-10-22 | UFC 50: The War of '04 | Welterweight | Matt Hughes def. Georges St-Pierre title | Submission (armbar) | 1 | 4:59 |
| 2004-06-19 | UFC 48: Payback | Welterweight | Matt Hughes def. Renato Verissimo | Decision (unanimous) (30–27, 29–28, 30–27) | 3 | 5:00 |
| 2004-01-31 | UFC 46: Supernatural | Welterweight | B.J. Penn def. Matt Hughes title | Submission (rear-naked choke) | 1 | 4:39 |
| 2003-11-21 | UFC 45: Revolution | Welterweight | Matt Hughes def. Frank Trigg title | Submission (standing rear-naked choke) | 1 | 3:54 |
| 2003-04-25 | UFC 42: Sudden Impact | Welterweight | Matt Hughes def. Sean Sherk title | Decision (unanimous) (49–46, 48–47, 48–45) | 5 | 5:00 |
| 2002-11-22 | UFC 40: Vendetta | Welterweight | Matt Hughes def. Gil Castillo title | TKO (doctor stoppage) | 1 | 5:00 |
| 2002-07-13 | UFC 38: Brawl at the Hall | Welterweight | Matt Hughes def. Carlos Newton title | TKO (punches) | 4 | 3:27 |
| 2002-03-22 | UFC 36: Worlds Collide | Welterweight | Matt Hughes def. Hayato Sakurai title | TKO (punches) | 4 | 3:01 |
| 2001-11-02 | UFC 34: High Voltage | Welterweight | Matt Hughes def. Carlos Newton title | KO (slam) | 2 | 1:27 |
| 2000-12-16 | UFC 29: Defense of the Belts | Welterweight | Dennis Hallman def. Matt Hughes | Submission (armbar) | 1 | 0:20 |
| 2000-06-09 | UFC 26: Ultimate Field of Dreams | Lightweight | Matt Hughes def. Marcelo Aguiar | TKO (doctor stoppage) | 1 | 4:34 |
| 1999-09-24 | UFC 22: Only One Can be Champion | Lightweight | Matt Hughes def. Valeri Ignatov | Decision (unanimous) | 3 | 5:00 |