| 2010-09-25 | UFC 119: Mir vs. Cro Cop | Welterweight | Chris Lytle def. Matt Serra | Decision (unanimous) (30–27, 30–27, 30–27) | 3 | 5:00 |
| 2010-02-06 | UFC 109: Relentless | Welterweight | Matt Serra def. Frank Trigg | TKO (punches) | 1 | 2:23 |
| 2009-05-23 | UFC 98: Evans vs. Machida | Welterweight | Matt Hughes def. Matt Serra | Decision (unanimous) (29-28, 29-28, 29-28) | 3 | 5:00 |
| 2008-04-19 | UFC 83: Serra vs. St-Pierre 2 | Welterweight | Georges St-Pierre def. Matt Serra title | TKO (knees) | 2 | 4:45 |
| 2007-04-07 | UFC 69: Shootout | Welterweight | Matt Serra def. Georges St-Pierre title | TKO (punches) | 1 | 3:25 |
| 2006-11-11 | The Ultimate Fighter: The Comeback Finale | Welterweight | Matt Serra def. Chris Lytle | Decision (split) (30–27, 27–30, 30–27) | 3 | 5:00 |
| 2005-06-04 | UFC 53: Heavy Hitters | Welterweight | Karo Parisyan def. Matt Serra | Decision (unanimous) (30–27, 30–27, 29–28) | 3 | 5:00 |
| 2004-06-19 | UFC 48: Payback | Lightweight | Matt Serra def. Ivan Menjivar | Decision (unanimous) (30–27, 30–27, 30–27) | 3 | 5:00 |
| 2004-01-31 | UFC 46: Supernatural | Lightweight | Matt Serra def. Jeff Curran | Decision (unanimous) (30–27, 30–27, 30–27) | 3 | 5:00 |
| 2003-02-28 | UFC 41: Onslaught | Lightweight | Din Thomas def. Matt Serra | Decision (split) | 3 | 5:00 |
| 2002-09-27 | UFC 39: The Warriors Return | Lightweight | B.J. Penn def. Matt Serra | Decision (unanimous) (29–28, 29–28, 29–28) | 3 | 5:00 |
| 2002-03-22 | UFC 36: Worlds Collide | Lightweight | Matt Serra def. Kelly Dullanty | Submission (triangle choke) | 1 | 2:58 |
| 2001-09-28 | UFC 33: Victory in Vegas | Welterweight | Matt Serra def. Yves Edwards | Decision (majority) (30–26, 30–27, 29–29) | 3 | 5:00 |
| 2001-05-04 | UFC 31: Locked and Loaded | Welterweight | Shonie Carter def. Matt Serra | KO (spinning back fist) | 3 | 4:51 |