| 2011-08-14 | UFC Live: Hardy vs. Lytle | Welterweight | Chris Lytle def. Dan Hardy | Submission (guillotine choke) | 3 | 4:16 |
| 2011-02-27 | UFC 127: Penn vs. Fitch | Welterweight | Brian Ebersole def. Chris Lytle | Decision (unanimous) (30–27, 29–28, 29–28) | 3 | 5:00 |
| 2010-09-25 | UFC 119: Mir vs. Cro Cop | Welterweight | Chris Lytle def. Matt Serra | Decision (unanimous) (30–27, 30–27, 30–27) | 3 | 5:00 |
| 2010-07-03 | UFC 116: Lesnar vs. Carwin | Welterweight | Chris Lytle def. Matt Brown | Submission (inverted triangle choke and straight armbar) | 2 | 2:02 |
| 2010-02-21 | UFC 110: Nogueira vs. Velasquez | Welterweight | Chris Lytle def. Brian Foster | Submission (kneebar) | 1 | 1:41 |
| 2009-06-20 | The Ultimate Fighter: United States vs. United Kingdom Finale | Welterweight | Chris Lytle def. Kevin Burns | Decision (unanimous) (29–28, 29–28, 29–28) | 3 | 5:00 |
| 2009-01-17 | UFC 93: Franklin vs. Henderson | Welterweight | Marcus Davis def. Chris Lytle | Decision (split) (29–28, 28–29, 29–28) | 3 | 5:00 |
| 2008-10-18 | UFC 89: Bisping vs. Leben | Welterweight | Chris Lytle def. Paul Taylor | Decision (unanimous) (29–28, 30–27, 29–28) | 3 | 5:00 |
| 2008-07-05 | UFC 86: Jackson vs. Griffin | Welterweight | Josh Koscheck def. Chris Lytle | Decision (unanimous) | 3 | 5:00 |
| 2008-02-02 | UFC 81: Breaking Point | Welterweight | Chris Lytle def. Kyle Bradley | TKO (punches) | 1 | 0:33 |
| 2007-11-17 | UFC 78: Validation | Welterweight | Thiago Alves def. Chris Lytle | TKO (doctor stoppage) | 2 | 5:00 |
| 2007-07-07 | UFC 73: Stacked | Welterweight | Chris Lytle def. Jason Gilliam | Submission (inverted triangle choke and americana) | 1 | 2:15 |
| 2007-03-03 | UFC 68: The Uprising | Welterweight | Matt Hughes def. Chris Lytle | Decision (unanimous) (30-27, 30-27, 30-27) | 3 | 5:00 |
| 2006-11-11 | The Ultimate Fighter: The Comeback Finale | Welterweight | Matt Serra def. Chris Lytle | Decision (split) (30–27, 27–30, 30–27) | 3 | 5:00 |
| 2005-10-07 | UFC 55: Fury | Welterweight | Joe Riggs def. Chris Lytle | TKO (cut) | 2 | 2:00 |
| 2005-02-05 | UFC 51: Super Saturday | Welterweight | Karo Parisyan def. Chris Lytle | Decision (unanimous) (30–27, 30–27, 30–27) | 3 | 5:00 |
| 2004-08-21 | UFC 49: Unfinished Business | Welterweight | Chris Lytle def. Ronald Jhun | Submission (guillotine choke) | 2 | 1:17 |
| 2004-04-02 | UFC 47: It's On! | Welterweight | Chris Lytle def. Tiki Ghosn | Submission (bulldog choke) | 2 | 1:55 |
| 2003-11-21 | UFC 45: Revolution | Welterweight | Robbie Lawler def. Chris Lytle | Decision (unanimous) (29–28, 29–28, 29–28) | 3 | 5:00 |
| 2000-11-17 | UFC 28: High Stakes | Lightweight | Ben Earwood def. Chris Lytle title | Decision (unanimous) | 2 | 5:00 |