| 2010-09-25 | UFC 119: Mir vs. Cro Cop | Lightweight | Sean Sherk def. Evan Dunham | Decision (split) (28–29, 29–28, 29–28) | 3 | 5:00 |
| 2009-05-23 | UFC 98: Evans vs. Machida | Lightweight | Frankie Edgar def. Sean Sherk | Decision (unanimous) (30-27, 30-27, 30-27) | 3 | 5:00 |
| 2008-10-25 | UFC 90: Silva vs. Côté | Lightweight | Sean Sherk def. Tyson Griffin | Decision (unanimous) (30–27, 29–28, 29–28) | 3 | 5:00 |
| 2008-05-24 | UFC 84: Ill Will | Lightweight | B.J. Penn def. Sean Sherk title | TKO (flying knee and punches) | 3 | 5:00 |
| 2007-07-07 | UFC 73: Stacked | Lightweight | Sean Sherk def. Hermes França title | Decision (unanimous) (50–45, 50–45, 49–46) | 5 | 5:00 |
| 2006-10-14 | UFC 64: Unstoppable | Lightweight | Sean Sherk def. Kenny Florian title | Decision (unanimous) (49–46, 49–46, 50–45) | 5 | 5:00 |
| 2006-04-15 | UFC 59: Reality Check | Welterweight | Sean Sherk def. Nick Diaz | Decision (unanimous) (30–27, 30–27, 30–27) | 3 | 5:00 |
| 2005-11-19 | UFC 56: Full Force | Welterweight | Georges St-Pierre def. Sean Sherk | TKO (punches and elbows) | 2 | 2:53 |
| 2003-04-25 | UFC 42: Sudden Impact | Welterweight | Matt Hughes def. Sean Sherk title | Decision (unanimous) (49–46, 48–47, 48–45) | 5 | 5:00 |
| 2002-09-27 | UFC 39: The Warriors Return | Welterweight | Sean Sherk def. Benji Radach | TKO (doctor stoppage) | 1 | 4:16 |
| 2002-03-22 | UFC 36: Worlds Collide | Welterweight | Sean Sherk def. Jutaro Nakao | Decision (unanimous) (30–27, 30–27, 30–27) | 3 | 5:00 |
| 2001-02-23 | UFC 30: Battle on the Boardwalk | Welterweight | Sean Sherk def. Tiki Ghosn | Verbal submission (dislocated shoulder) | 2 | 4:47 |