| 2023-05-13 | UFC on ABC: Rozenstruik vs. Almeida | Welterweight | Matt Brown def. Court McGee | KO (punch) | 1 | 4:09 |
| 2022-03-26 | UFC on ESPN: Blaydes vs. Daukaus | Welterweight | Bryan Barberena def. Matt Brown | Decision (split) (29–28, 28–29, 29–28) | 3 | 5:00 |
| 2021-06-19 | UFC on ESPN: The Korean Zombie vs. Ige | Welterweight | Matt Brown def. Dhiego Lima | KO (punch) | 2 | 3:02 |
| 2021-01-16 | UFC on ABC: Holloway vs. Kattar | Welterweight | Carlos Condit def. Matt Brown | Decision (unanimous) (30–27, 30–27, 30–27) | 3 | 5:00 |
| 2020-05-16 | UFC on ESPN: Overeem vs. Harris | Welterweight | Miguel Baeza def. Matt Brown | TKO (punches) | 2 | 0:18 |
| 2019-12-14 | UFC 245: Usman vs. Covington | Welterweight | Matt Brown def. Ben Saunders | KO (elbows and punches) | 2 | 4:55 |
| 2017-11-11 | UFC Fight Night: Poirier vs. Pettis | Welterweight | Matt Brown def. Diego Sanchez | KO (elbow) | 1 | 3:44 |
| 2016-12-10 | UFC 206: Holloway vs. Pettis | Welterweight | Donald Cerrone def. Matt Brown | KO (Head Kick) | 3 | 0:34 |
| 2016-07-30 | UFC 201: Lawler vs. Woodley | Welterweight | Jake Ellenberger def. Matt Brown | TKO (body kick and punches) | 1 | 1:46 |
| 2016-05-14 | UFC 198: Werdum vs. Miocic | Welterweight | Demian Maia def. Matt Brown | Submission (rear-naked choke) | 3 | 4:31 |
| 2015-07-11 | UFC 189: Mendes vs. McGregor | Welterweight | Matt Brown def. Tim Means | Submission (guillotine choke) | 1 | 4:44 |
| 2015-03-14 | UFC 185: Pettis vs. dos Anjos | Welterweight | Johny Hendricks def. Matt Brown | Decision (unanimous) (30–27, 30–27, 30–27) | 3 | 5:00 |
| 2014-07-26 | UFC on Fox: Lawler vs. Brown | Catchweight | Robbie Lawler def. Matt Brown | Decision (unanimous) (49–46, 49–46, 48–47) | 5 | 5:00 |
| 2014-05-10 | UFC Fight Night: Brown vs. Silva | Welterweight | Matt Brown def. Erick Silva | TKO (punches) | 3 | 2:11 |
| 2013-08-17 | UFC Fight Night: Shogun vs. Sonnen | Welterweight | Matt Brown def. Mike Pyle | KO (punches) | 1 | 0:29 |
| 2013-04-20 | UFC on Fox: Henderson vs. Melendez | Welterweight | Matt Brown def. Jordan Mein | TKO (elbows to the body) | 2 | 1:00 |
| 2012-12-08 | UFC on Fox: Henderson vs. Diaz | Welterweight | Matt Brown def. Mike Swick | KO (punches) | 2 | 2:31 |
| 2012-06-22 | UFC on FX: Maynard vs. Guida | Welterweight | Matt Brown def. Luis Ramos | TKO (knees and punches) | 2 | 4:20 |
| 2012-04-21 | UFC 145: Jones vs. Evans | Welterweight | Matt Brown def. Stephen Thompson | Decision (unanimous) (30–27, 29–27, 30–27) | 3 | 5:00 |
| 2012-02-04 | UFC 143: Diaz vs. Condit | Welterweight | Matt Brown def. Chris Cope | KO (punches) | 2 | 1:19 |
| 2011-11-19 | UFC 139: Shogun vs. Henderson | Welterweight | Seth Baczynski def. Matt Brown | Submission (guillotine choke) | 2 | 0:42 |
| 2011-06-26 | UFC Live: Kongo vs. Barry | Welterweight | Matt Brown def. John Howard | Decision (unanimous) (29–28, 29–28, 29–28) | 3 | 5:00 |
| 2010-11-20 | UFC 123: Rampage vs. Machida | Welterweight | Brian Foster def. Matt Brown | Submission (guillotine choke) | 2 | 2:11 |
| 2010-07-03 | UFC 116: Lesnar vs. Carwin | Welterweight | Chris Lytle def. Matt Brown | Submission (inverted triangle choke and straight armbar) | 2 | 2:02 |
| 2010-03-27 | UFC 111: St-Pierre vs. Hardy | Welterweight | Ricardo Almeida def. Matt Brown | Submission (rear-naked choke) | 2 | 3:30 |
| 2009-11-14 | UFC 105: Couture vs. Vera | Welterweight | Matt Brown def. James Wilks | TKO (punches) | 3 | 2:27 |
| 2009-03-07 | UFC 96: Jackson vs. Jardine | Welterweight | Matt Brown def. Pete Sell | TKO (punches) | 1 | 1:32 |
| 2008-11-15 | UFC 91: Couture vs. Lesnar | Welterweight | Matt Brown def. Ryan Thomas | Submission (armbar) | 2 | 0:57 |
| 2008-09-06 | UFC 88: Breakthrough | Welterweight | Kim Dong-hyun def. Matt Brown | Decision (split) (29–28, 28–29, 29–28) | 3 | 5:00 |
| 2008-06-21 | The Ultimate Fighter: Team Rampage vs. Team Forrest Finale | Welterweight | Matt Brown def. Matt Arroyo | TKO (punches) | 2 | 3:40 |