| 2026-06-14 | UFC Freedom 250 | Heavyweight | Josh Hokit def. Derrick Lewis | TKO (punches) | 2 | 4:09 |
| 2026-01-24 | UFC 324: Gaethje vs. Pimblett | Heavyweight | Waldo Cortes-Acosta def. Derrick Lewis | TKO (punches) | 2 | 3:14 |
| 2025-07-12 | UFC on ESPN: Lewis vs. Teixeira | Heavyweight | Derrick Lewis def. Tallison Teixeira | TKO (punches) | 1 | 0:35 |
| 2024-05-11 | UFC on ESPN: Lewis vs. Nascimento | Heavyweight | Derrick Lewis def. Rodrigo Nascimento | TKO (punches) | 3 | 0:49 |
| 2023-11-04 | UFC Fight Night: Almeida vs. Lewis | Heavyweight | Jailton Almeida def. Derrick Lewis | Decision (unanimous) (50–44, 50–44, 50–45) | 5 | 5:00 |
| 2023-07-29 | UFC 291: Poirier vs. Gaethje 2 | Heavyweight | Derrick Lewis def. Marcos Rogério de Lima | TKO (punches) | 1 | 0:33 |
| 2023-02-04 | UFC Fight Night: Lewis vs. Spivac | Heavyweight | Serghei Spivac def. Derrick Lewis | Submission (arm-triangle choke) | 1 | 3:05 |
| 2022-07-30 | UFC 277: Peña vs. Nunes 2 | Heavyweight | Sergei Pavlovich def. Derrick Lewis | TKO (punches) | 1 | 0:55 |
| 2022-02-12 | UFC 271: Adesanya vs. Whittaker 2 | Heavyweight | Tai Tuivasa def. Derrick Lewis | KO (elbow) | 2 | 1:40 |
| 2021-12-18 | UFC Fight Night: Lewis vs. Daukaus | Heavyweight | Derrick Lewis def. Chris Daukaus | KO (punches) | 1 | 3:36 |
| 2021-08-07 | UFC 265: Lewis vs. Gane | Heavyweight | Ciryl Gane def. Derrick Lewis title | TKO (punches) | 3 | 4:11 |
| 2021-02-20 | UFC Fight Night: Blaydes vs. Lewis | Heavyweight | Derrick Lewis def. Curtis Blaydes | KO (punch) | 2 | 1:26 |
| 2020-08-08 | UFC Fight Night: Lewis vs. Oleinik | Heavyweight | Derrick Lewis def. Aleksei Oleinik | TKO (punches) | 2 | 0:21 |
| 2020-02-08 | UFC 247: Jones vs. Reyes | Heavyweight | Derrick Lewis def. Ilir Latifi | Decision (unanimous) (29–28, 29–28, 29–28) | 3 | 5:00 |
| 2019-11-02 | UFC 244: Masvidal vs. Diaz | Heavyweight | Derrick Lewis def. Blagoy Ivanov | Decision (split) (30–27, 28–29, 29–28) | 3 | 5:00 |
| 2019-03-09 | UFC Fight Night: Lewis vs. dos Santos | Heavyweight | Junior dos Santos def. Derrick Lewis | TKO (punches) | 2 | 1:58 |
| 2018-11-03 | UFC 230: Cormier vs. Lewis | Heavyweight | Daniel Cormier def. Derrick Lewis title | Submission (rear-naked choke) | 2 | 2:14 |
| 2018-10-06 | UFC 229: Khabib vs. McGregor | Heavyweight | Derrick Lewis def. Alexander Volkov | KO (punches) | 3 | 4:49 |
| 2018-07-07 | UFC 226: Miocic vs. Cormier | Heavyweight | Derrick Lewis def. Francis Ngannou | Decision (unanimous) (29–28, 29–28, 30–27) | 3 | 5:00 |
| 2018-02-18 | UFC Fight Night: Cowboy vs. Medeiros | Heavyweight | Derrick Lewis def. Marcin Tybura | KO (punches) | 3 | 2:48 |
| 2017-06-11 | UFC Fight Night: Lewis vs. Hunt | Heavyweight | Mark Hunt def. Derrick Lewis | TKO (punches) | 4 | 3:51 |
| 2017-02-19 | UFC Fight Night: Lewis vs. Browne | Heavyweight | Derrick Lewis def. Travis Browne | KO (punches) | 2 | 3:12 |
| 2016-12-09 | UFC Fight Night: Lewis vs. Abdurakhimov | Heavyweight | Derrick Lewis def. Shamil Abdurakhimov | TKO (punches) | 4 | 3:42 |
| 2016-07-07 | UFC Fight Night: dos Anjos vs. Alvarez | Heavyweight | Derrick Lewis def. Roy Nelson | Decision (split) (29–28, 28–29, 29–28) | 3 | 5:00 |
| 2016-04-10 | UFC Fight Night: Rothwell vs. dos Santos | Heavyweight | Derrick Lewis def. Gabriel Gonzaga | KO (punches) | 1 | 4:48 |
| 2016-02-06 | UFC Fight Night: Hendricks vs. Thompson | Heavyweight | Derrick Lewis def. Damian Grabowski | TKO (punches) | 1 | 2:17 |
| 2015-10-03 | UFC 192: Cormier vs. Gustafsson | Heavyweight | Derrick Lewis def. Viktor Pešta | TKO (punches) | 3 | 1:15 |
| 2015-06-06 | UFC Fight Night: Boetsch vs. Henderson | Heavyweight | Shawn Jordan def. Derrick Lewis | TKO (hook kick and punches) | 2 | 0:48 |
| 2015-02-28 | UFC 184: Rousey vs. Zingano | Heavyweight | Derrick Lewis def. Ruan Potts | TKO (punches) | 2 | 3:18 |
| 2014-09-05 | UFC Fight Night: Jacaré vs. Mousasi | Heavyweight | Matt Mitrione def. Derrick Lewis | KO (punches) | 1 | 0:41 |
| 2014-07-06 | The Ultimate Fighter: Team Edgar vs. Team Penn Finale | Heavyweight | Derrick Lewis def. Guto Inocente | TKO (punches) | 1 | 3:30 |
| 2014-04-19 | UFC on Fox: Werdum vs. Browne | Heavyweight | Derrick Lewis def. Jack May | TKO (punches) | 1 | 4:23 |