| 2017-04-15 | UFC on Fox: Johnson vs. Reis | Heavyweight | Alexander Volkov def. Roy Nelson | Decision (unanimous) (30–27, 30–27, 30–27) | 3 | 5:00 |
| 2016-09-24 | UFC Fight Night: Cyborg vs. Länsberg | Heavyweight | Roy Nelson def. Antônio Silva | KO (punches) | 2 | 4:10 |
| 2016-07-07 | UFC Fight Night: dos Anjos vs. Alvarez | Heavyweight | Derrick Lewis def. Roy Nelson | Decision (split) (29–28, 28–29, 29–28) | 3 | 5:00 |
| 2016-02-06 | UFC Fight Night: Hendricks vs. Thompson | Heavyweight | Roy Nelson def. Jared Rosholt | Decision (unanimous) (30–27, 30–27, 29–28) | 3 | 5:00 |
| 2015-09-27 | UFC Fight Night: Barnett vs. Nelson | Heavyweight | Josh Barnett def. Roy Nelson | Decision (unanimous) (48–47, 48–47, 50–45) | 5 | 5:00 |
| 2015-03-14 | UFC 185: Pettis vs. dos Anjos | Heavyweight | Alistair Overeem def. Roy Nelson | Decision (unanimous) (30–27, 30–27, 30–27) | 3 | 5:00 |
| 2014-09-20 | UFC Fight Night: Hunt vs. Nelson | Heavyweight | Mark Hunt def. Roy Nelson | KO (punch) | 2 | 3:00 |
| 2014-04-11 | UFC Fight Night: Nogueira vs. Nelson | Heavyweight | Roy Nelson def. Antônio Rodrigo Nogueira | KO (punch) | 1 | 3:37 |
| 2013-10-19 | UFC 166: Velasquez vs. dos Santos III | Heavyweight | Daniel Cormier def. Roy Nelson | Decision (unanimous) (30–27, 30–27, 30–27) | 3 | 5:00 |
| 2013-06-15 | UFC 161: Evans vs. Henderson | Heavyweight | Stipe Miocic def. Roy Nelson | Decision (unanimous) (30–27, 30–27, 30–27) | 3 | 5:00 |
| 2013-04-27 | UFC 159: Jones vs. Sonnen | Heavyweight | Roy Nelson def. Cheick Kongo | KO (punches) | 1 | 2:03 |
| 2012-12-15 | The Ultimate Fighter: Team Carwin vs. Team Nelson Finale | Heavyweight | Roy Nelson def. Matt Mitrione | TKO (punches) | 1 | 2:58 |
| 2012-05-26 | UFC 146: dos Santos vs. Mir | Heavyweight | Roy Nelson def. Dave Herman | KO (punch) | 1 | 0:51 |
| 2012-02-04 | UFC 143: Diaz vs. Condit | Heavyweight | Fabrício Werdum def. Roy Nelson | Decision (unanimous) (30–27, 30–27, 30–27) | 3 | 5:00 |
| 2011-10-29 | UFC 137: Penn vs. Diaz | Heavyweight | Roy Nelson def. Mirko Cro Cop | TKO (punches) | 3 | 1:30 |
| 2011-05-28 | UFC 130: Rampage vs. Hamill | Heavyweight | Frank Mir def. Roy Nelson | Decision (unanimous) (30–27, 30–27, 30–26) | 3 | 5:00 |
| 2010-08-07 | UFC 117: Silva vs. Sonnen | Heavyweight | Junior dos Santos def. Roy Nelson | Decision (unanimous) (30–26, 30–27, 30–27) | 3 | 5:00 |
| 2010-03-31 | UFC Fight Night: Florian vs. Gomi | Heavyweight | Roy Nelson def. Stefan Struve | TKO (punches) | 1 | 0:39 |
| 2009-12-05 | The Ultimate Fighter: Heavyweights Finale | Heavyweight | Roy Nelson def. Brendan Schaub | KO (punch) | 1 | 3:45 |