| 2016-01-17 | UFC Fight Night: Dillashaw vs. Cruz | Heavyweight | Travis Browne def. Matt Mitrione | TKO (punches) | 3 | 4:09 |
| 2015-06-06 | UFC Fight Night: Boetsch vs. Henderson | Heavyweight | Ben Rothwell def. Matt Mitrione | Submission (guillotine choke) | 1 | 1:54 |
| 2014-12-13 | UFC on Fox: dos Santos vs. Miocic | Heavyweight | Matt Mitrione def. Gabriel Gonzaga | TKO (punches) | 1 | 1:59 |
| 2014-09-05 | UFC Fight Night: Jacaré vs. Mousasi | Heavyweight | Matt Mitrione def. Derrick Lewis | KO (punches) | 1 | 0:41 |
| 2014-03-01 | The Ultimate Fighter China Finale: Kim vs. Hathaway | Heavyweight | Matt Mitrione def. Shawn Jordan | KO (punches) | 1 | 4:59 |
| 2013-09-21 | UFC 165: Jones vs. Gustafsson | Heavyweight | Brendan Schaub def. Matt Mitrione | Technical Submission (D'Arce choke) | 1 | 4:06 |
| 2013-04-06 | UFC on Fuel TV: Mousasi vs. Latifi | Heavyweight | Matt Mitrione def. Phil De Fries | KO (punches) | 1 | 0:19 |
| 2012-12-15 | The Ultimate Fighter: Team Carwin vs. Team Nelson Finale | Heavyweight | Roy Nelson def. Matt Mitrione | TKO (punches) | 1 | 2:58 |
| 2011-10-29 | UFC 137: Penn vs. Diaz | Heavyweight | Cheick Kongo def. Matt Mitrione | Decision (unanimous) (30–27, 30–28, 29–28) | 3 | 5:00 |
| 2011-06-26 | UFC Live: Kongo vs. Barry | Heavyweight | Matt Mitrione def. Christian Morecraft | KO (punches) | 2 | 4:28 |
| 2011-01-22 | UFC: Fight for the Troops 2 | Heavyweight | Matt Mitrione def. Tim Hague | TKO (punches) | 1 | 2:59 |
| 2010-09-25 | UFC 119: Mir vs. Cro Cop | Heavyweight | Matt Mitrione def. Joey Beltran | Decision (unanimous) (29–28, 29–28, 29–28) | 3 | 5:00 |
| 2010-05-08 | UFC 113: Machida vs. Shogun 2 | Heavyweight | Matt Mitrione def. Kimbo Slice | TKO (punches) | 2 | 4:24 |
| 2009-12-05 | The Ultimate Fighter: Heavyweights Finale | Heavyweight | Matt Mitrione def. Marcus Jones | KO (punch) | 2 | 0:10 |