| 2018-03-03 | UFC 222: Cyborg vs. Kunitskaya | Welterweight | Zak Ottow def. Mike Pyle | TKO (punches) | 1 | 2:34 |
| 2016-12-30 | UFC 207: Nunes vs. Rousey | Welterweight | Alex Garcia def. Mike Pyle | KO (punch) | 1 | 3:34 |
| 2016-07-07 | UFC Fight Night: dos Anjos vs. Alvarez | Welterweight | Alberto Mina def. Mike Pyle | KO (flying knee and punches) | 2 | 1:17 |
| 2016-02-06 | UFC Fight Night: Hendricks vs. Thompson | Welterweight | Mike Pyle def. Sean Spencer | TKO (elbows and knees) | 3 | 4:25 |
| 2015-05-23 | UFC 187: Johnson vs. Cormier | Welterweight | Colby Covington def. Mike Pyle | Decision (unanimous) (30–27, 29–28, 30–27) | 3 | 5:00 |
| 2014-08-23 | UFC Fight Night: Henderson vs. dos Anjos | Welterweight | Jordan Mein def. Mike Pyle | TKO (punches) | 1 | 1:12 |
| 2014-02-22 | UFC 170: Rousey vs. McMann | Welterweight | Mike Pyle def. TJ Waldburger | TKO (elbows and punches) | 3 | 4:03 |
| 2013-08-17 | UFC Fight Night: Shogun vs. Sonnen | Welterweight | Matt Brown def. Mike Pyle | KO (punches) | 1 | 0:29 |
| 2013-05-25 | UFC 160: Velasquez vs. Bigfoot 2 | Welterweight | Mike Pyle def. Rick Story | Decision (split) (28–29, 29–28, 29–28) | 3 | 5:00 |
| 2012-12-15 | The Ultimate Fighter: Team Carwin vs. Team Nelson Finale | Welterweight | Mike Pyle def. James Head | TKO (knee and punches) | 1 | 1:55 |
| 2012-06-08 | UFC on FX: Johnson vs. McCall 2 | Welterweight | Mike Pyle def. Josh Neer | KO (punch) | 1 | 4:56 |
| 2012-01-14 | UFC 142: Aldo vs. Mendes | Welterweight | Mike Pyle def. Ricardo Funch | TKO (knee and punches) | 1 | 1:22 |
| 2011-08-06 | UFC 133: Evans vs. Ortiz | Welterweight | Rory MacDonald def. Mike Pyle | TKO (punches) | 1 | 3:54 |
| 2011-03-19 | UFC 128: Shogun vs. Jones | Welterweight | Mike Pyle def. Ricardo Almeida | Decision (unanimous) (29–28, 29–28, 29–28) | 3 | 5:00 |
| 2010-10-16 | UFC 120: Bisping vs. Akiyama | Welterweight | Mike Pyle def. John Hathaway | Decision (unanimous) (30–27, 30–27, 30–27) | 3 | 5:00 |
| 2010-06-12 | UFC 115: Liddell vs. Franklin | Welterweight | Mike Pyle def. Jesse Lennox | Submission (triangle choke) | 3 | 4:44 |
| 2010-01-02 | UFC 108: Evans vs. Silva | Welterweight | Jake Ellenberger def. Mike Pyle | TKO (punches) | 2 | 0:22 |
| 2009-09-16 | UFC Fight Night: Diaz vs. Guillard | Welterweight | Mike Pyle def. Chris Wilson | Submission (guillotine choke) | 3 | 2:15 |
| 2009-05-23 | UFC 98: Evans vs. Machida | Catchweight | Brock Larson def. Mike Pyle | Submission (arm-triangle choke) | 1 | 3:06 |