| 2026-07-18 | UFC Fight Night: du Plessis vs. Usman | Middleweight | Dricus du Plessis def. Kamaru Usman | Decision (unanimous) (50–45, 49–46, 49–46) | 5 | 5:00 |
| 2025-08-16 | UFC 319: du Plessis vs. Chimaev | Middleweight | Khamzat Chimaev def. Dricus du Plessis title | Decision (unanimous) (50–44, 50–44, 50–44) | 5 | 5:00 |
| 2025-02-08 | UFC 312: du Plessis vs. Strickland 2 | Middleweight | Dricus du Plessis def. Sean Strickland title | Decision (unanimous) (50–45, 50–45, 49–46) | 5 | 5:00 |
| 2024-08-18 | UFC 305: du Plessis vs. Adesanya | Middleweight | Dricus du Plessis def. Israel Adesanya title | Submission (face crank) | 4 | 3:38 |
| 2024-01-20 | UFC 297: Strickland vs. du Plessis | Middleweight | Dricus du Plessis def. Sean Strickland title | Decision (split) (47–48, 48–47, 48–47) | 5 | 5:00 |
| 2023-07-08 | UFC 290: Volkanovski vs. Rodríguez | Middleweight | Dricus du Plessis def. Robert Whittaker | TKO (punches) | 2 | 2:23 |
| 2023-03-04 | UFC 285: Jones vs. Gane | Middleweight | Dricus du Plessis def. Derek Brunson | TKO (corner stoppage) | 2 | 4:59 |
| 2022-12-10 | UFC 282: Błachowicz vs. Ankalaev | Middleweight | Dricus du Plessis def. Darren Till | Submission (face crank) | 3 | 2:43 |
| 2022-07-02 | UFC 276: Adesanya vs. Cannonier | Middleweight | Dricus du Plessis def. Brad Tavares | Decision (unanimous) (29–28, 29–28, 29–28) | 3 | 5:00 |
| 2021-07-10 | UFC 264: Poirier vs. McGregor 3 | Middleweight | Dricus du Plessis def. Trevin Giles | KO (punches) | 2 | 1:41 |
| 2020-10-11 | UFC Fight Night: Moraes vs. Sandhagen | Middleweight | Dricus du Plessis def. Markus Perez Echeimberg | KO (punches) | 1 | 3:22 |