| 2020-03-07 | UFC 248: Adesanya vs. Romero | Middleweight | Israel Adesanya def. Yoel Romero title | Decision (unanimous) (48–47, 48–47, 49–46) | 5 | 5:00 |
| 2019-08-17 | UFC 241: Cormier vs. Miocic 2 | Middleweight | Paulo Costa def. Yoel Romero | Decision (unanimous) (29–28, 29–28, 29–28) | 3 | 5:00 |
| 2018-06-09 | UFC 225: Whittaker vs. Romero 2 | Middleweight | Robert Whittaker def. Yoel Romero | Decision (split) (47–48, 48–47, 48–47) | 5 | 5:00 |
| 2018-02-11 | UFC 221: Romero vs. Rockhold | Catchweight | Yoel Romero def. Luke Rockhold title | KO (punches) | 3 | 1:48 |
| 2017-07-08 | UFC 213: Romero vs. Whittaker | Middleweight | Robert Whittaker def. Yoel Romero title | Decision (unanimous) (48–47, 48–47, 48–47) | 5 | 5:00 |
| 2016-11-12 | UFC 205: Alvarez vs. McGregor | Middleweight | Yoel Romero def. Chris Weidman | KO (flying knee and punches) | 3 | 0:24 |
| 2015-12-12 | UFC 194: Aldo vs. McGregor | Middleweight | Yoel Romero def. Ronaldo Souza | Decision (split) (29–27, 28–29, 29–28) | 3 | 5:00 |
| 2015-06-27 | UFC Fight Night: Machida vs. Romero | Middleweight | Yoel Romero def. Lyoto Machida | KO (elbows) | 3 | 1:38 |
| 2014-09-27 | UFC 178: Johnson vs. Cariaso | Middleweight | Yoel Romero def. Tim Kennedy | TKO (punches) | 3 | 0:58 |
| 2014-04-19 | UFC on Fox: Werdum vs. Browne | Middleweight | Yoel Romero def. Brad Tavares | Decision (unanimous) (30–27, 30–27, 30–27) | 3 | 5:00 |
| 2014-01-15 | UFC Fight Night: Rockhold vs. Philippou | Middleweight | Yoel Romero def. Derek Brunson | TKO (punches and elbows) | 3 | 3:23 |
| 2013-11-06 | UFC: Fight for the Troops 3 | Middleweight | Yoel Romero def. Ronny Markes | KO (punches) | 3 | 1:39 |
| 2013-04-20 | UFC on Fox: Henderson vs. Melendez | Middleweight | Yoel Romero def. Clifford Starks | KO (flying knee and punches) | 1 | 1:32 |