| 2023-03-04 | UFC 285: Jones vs. Gane | Middleweight | Dricus du Plessis def. Derek Brunson | TKO (corner stoppage) | 2 | 4:59 |
| 2022-02-12 | UFC 271: Adesanya vs. Whittaker 2 | Middleweight | Jared Cannonier def. Derek Brunson | KO (elbows) | 2 | 4:29 |
| 2021-09-04 | UFC Fight Night: Brunson vs. Till | Middleweight | Derek Brunson def. Darren Till | Submission (rear-naked choke) | 3 | 2:13 |
| 2021-03-20 | UFC on ESPN: Brunson vs. Holland | Middleweight | Derek Brunson def. Kevin Holland | Decision (unanimous) (49–45, 49–46, 49–46) | 5 | 5:00 |
| 2020-08-01 | UFC Fight Night: Brunson vs. Shahbazyan | Middleweight | Derek Brunson def. Edmen Shahbazyan | TKO (punches) | 3 | 0:26 |
| 2019-08-17 | UFC 241: Cormier vs. Miocic 2 | Middleweight | Derek Brunson def. Ian Heinisch | Decision (unanimous) (29–28, 29–28, 29–28) | 3 | 5:00 |
| 2019-05-04 | UFC Fight Night: Iaquinta vs. Cowboy | Middleweight | Derek Brunson def. Elias Theodorou | Decision (unanimous) (29–28, 29–28, 30–27) | 3 | 5:00 |
| 2018-11-03 | UFC 230: Cormier vs. Lewis | Middleweight | Israel Adesanya def. Derek Brunson | TKO (knees and punches) | 1 | 4:51 |
| 2018-01-27 | UFC on Fox: Jacaré vs. Brunson 2 | Middleweight | Ronaldo Souza def. Derek Brunson | KO (head kick and punches) | 1 | 3:50 |
| 2017-10-28 | UFC Fight Night: Brunson vs. Machida | Middleweight | Derek Brunson def. Lyoto Machida | KO (punches) | 1 | 2:30 |
| 2017-06-11 | UFC Fight Night: Lewis vs. Hunt | Middleweight | Derek Brunson def. Dan Kelly | KO (punches) | 1 | 1:16 |
| 2017-02-11 | UFC 208: Holm vs. de Randamie | Middleweight | Anderson Silva def. Derek Brunson | Decision (unanimous) (29–28, 29–28, 30–27) | 3 | 5:00 |
| 2016-11-27 | UFC Fight Night: Whittaker vs. Brunson | Middleweight | Robert Whittaker def. Derek Brunson | TKO (head kick and punches) | 1 | 4:07 |
| 2016-09-17 | UFC Fight Night: Poirier vs. Johnson | Middleweight | Derek Brunson def. Uriah Hall | TKO (punch) | 1 | 1:41 |
| 2016-02-21 | UFC Fight Night: Cowboy vs. Cowboy | Middleweight | Derek Brunson def. Roan Carneiro | TKO (punches) | 1 | 2:38 |
| 2015-08-08 | UFC Fight Night: Teixeira vs. Saint Preux | Middleweight | Derek Brunson def. Sam Alvey | TKO (punches) | 1 | 2:19 |
| 2015-01-31 | UFC 183: Silva vs. Diaz | Middleweight | Derek Brunson def. Ed Herman | TKO (punches) | 1 | 0:36 |
| 2014-08-30 | UFC 177: Dillashaw vs. Soto | Middleweight | Derek Brunson def. Lorenz Larkin | Decision (unanimous) (30–27, 30–27, 30–27) | 3 | 5:00 |
| 2014-01-15 | UFC Fight Night: Rockhold vs. Philippou | Middleweight | Yoel Romero def. Derek Brunson | TKO (punches and elbows) | 3 | 3:23 |
| 2013-11-06 | UFC: Fight for the Troops 3 | Middleweight | Derek Brunson def. Brian Houston | Submission (rear-naked choke) | 1 | 0:48 |
| 2012-12-29 | UFC 155: dos Santos vs. Velasquez 2 | Middleweight | Derek Brunson def. Chris Leben | Decision (unanimous) (29–28, 29–28, 29–28) | 3 | 5:00 |