| 2022-11-12 | UFC 281: Adesanya vs. Pereira | Bantamweight | Chris Gutiérrez def. Frankie Edgar | KO (knee) | 1 | 2:01 |
| 2021-11-06 | UFC 268: Usman vs. Covington 2 | Bantamweight | Marlon Vera def. Frankie Edgar | KO (front kick) | 3 | 3:50 |
| 2021-02-06 | UFC Fight Night: Overeem vs. Volkov | Bantamweight | Cory Sandhagen def. Frankie Edgar | KO (flying knee) | 1 | 0:28 |
| 2020-08-22 | UFC on ESPN: Munhoz vs. Edgar | Bantamweight | Frankie Edgar def. Pedro Munhoz | Decision (split) (48–47, 46–49, 48–47) | 5 | 5:00 |
| 2019-12-21 | UFC Fight Night: Edgar vs. The Korean Zombie | Featherweight | Chan Sung Jung def. Frankie Edgar | TKO (punches) | 1 | 3:18 |
| 2019-07-27 | UFC 240: Holloway vs. Edgar | Featherweight | Max Holloway def. Frankie Edgar title | Decision (unanimous) (50–45, 49–46, 48–47) | 5 | 5:00 |
| 2018-04-21 | UFC Fight Night: Barboza vs. Lee | Featherweight | Frankie Edgar def. Cub Swanson | Decision (unanimous) (30–27, 30–27, 30–27) | 3 | 5:00 |
| 2018-03-03 | UFC 222: Cyborg vs. Kunitskaya | Featherweight | Brian Ortega def. Frankie Edgar | KO (punch) | 1 | 4:44 |
| 2017-05-13 | UFC 211: Miocic vs. dos Santos 2 | Featherweight | Frankie Edgar def. Yair Rodríguez | TKO (doctor stoppage) | 2 | 5:00 |
| 2016-11-12 | UFC 205: Alvarez vs. McGregor | Featherweight | Frankie Edgar def. Jeremy Stephens | Decision (unanimous) (29-28, 30-27, 30-27) | 3 | 5:00 |
| 2016-07-09 | UFC 200: Tate vs. Nunes | Featherweight | José Aldo def. Frankie Edgar title | Decision (unanimous) (49–46, 49–46, 48–47) | 5 | 5:00 |
| 2015-12-11 | The Ultimate Fighter: Team McGregor vs. Team Faber Finale | Featherweight | Frankie Edgar def. Chad Mendes | KO (punch) | 1 | 2:28 |
| 2015-05-16 | UFC Fight Night: Edgar vs. Faber | Featherweight | Frankie Edgar def. Urijah Faber | Decision (unanimous) (50–45, 50–45, 50–45) | 5 | 5:00 |
| 2014-11-22 | UFC Fight Night: Edgar vs. Swanson | Featherweight | Frankie Edgar def. Cub Swanson | Submission (neck crank) | 5 | 4:56 |
| 2014-07-06 | The Ultimate Fighter: Team Edgar vs. Team Penn Finale | Featherweight | Frankie Edgar def. B.J. Penn | TKO (punches) | 3 | 4:16 |
| 2013-07-06 | UFC 162: Silva vs. Weidman | Featherweight | Frankie Edgar def. Charles Oliveira | Decision (unanimous) (30–27, 29–28, 30–27) | 3 | 5:00 |
| 2013-02-02 | UFC 156: Aldo vs. Edgar | Featherweight | José Aldo def. Frankie Edgar title | Decision (unanimous) (49–46, 49–46, 48–47) | 5 | 5:00 |
| 2012-08-11 | UFC 150: Henderson vs. Edgar II | Lightweight | Benson Henderson def. Frankie Edgar title | Decision (split) (46–49, 48–47, 48–47) | 5 | 5:00 |
| 2012-02-26 | UFC 144: Edgar vs. Henderson | Lightweight | Benson Henderson def. Frankie Edgar title | Decision (unanimous) (49–46, 48–47, 49–46) | 5 | 5:00 |
| 2011-10-08 | UFC 136: Edgar vs. Maynard III | Lightweight | Frankie Edgar def. Gray Maynard title | TKO (punches) | 4 | 3:54 |
| 2011-01-01 | UFC 125: Resolution | Lightweight | Frankie Edgar vs. Gray Maynard title | Draw (split) (46–48, 48–46, 47–47) | 5 | 5:00 |
| 2010-08-28 | UFC 118: Edgar vs. Penn 2 | Lightweight | Frankie Edgar def. B.J. Penn title | Decision (unanimous) (50–45, 50–45, 50–45) | 5 | 5:00 |
| 2010-04-10 | UFC 112: Invincible | Lightweight | Frankie Edgar def. B.J. Penn title | Decision (unanimous) (50–45, 48–47, 49–46) | 5 | 5:00 |
| 2009-12-05 | The Ultimate Fighter: Heavyweights Finale | Lightweight | Frankie Edgar def. Matt Veach | Submission (rear-naked choke) | 2 | 2:22 |
| 2009-05-23 | UFC 98: Evans vs. Machida | Lightweight | Frankie Edgar def. Sean Sherk | Decision (unanimous) (30-27, 30-27, 30-27) | 3 | 5:00 |
| 2008-07-19 | UFC Fight Night: Silva vs. Irvin | Lightweight | Frankie Edgar def. Hermes França | Decision (unanimous) (30–27, 30–27, 30–27) | 3 | 5:00 |
| 2008-04-02 | UFC Fight Night: Florian vs. Lauzon | Lightweight | Gray Maynard def. Frankie Edgar | Decision (unanimous) (30–27, 30–27, 30–27) | 3 | 5:00 |
| 2007-11-17 | UFC 78: Validation | Lightweight | Frankie Edgar def. Spencer Fisher | Decision (unanimous) (30–27, 30–27, 30–26) | 3 | 5:00 |
| 2007-07-07 | UFC 73: Stacked | Lightweight | Frankie Edgar def. Mark Bocek | TKO (punches) | 1 | 4:55 |
| 2007-02-03 | UFC 67: All or Nothing | Lightweight | Frankie Edgar def. Tyson Griffin | Decision (unanimous) (29–28, 29–28, 30–27) | 3 | 5:00 |