| 2012-06-22 | UFC on FX: Maynard vs. Guida | Lightweight | Sam Stout def. Spencer Fisher | Decision (unanimous) (30–27, 30–27, 30–27) | 3 | 5:00 |
| 2011-08-27 | UFC 134: Silva vs. Okami | Lightweight | Thiago Tavares def. Spencer Fisher | TKO (punches) | 2 | 2:51 |
| 2011-02-27 | UFC 127: Penn vs. Fitch | Lightweight | Ross Pearson def. Spencer Fisher | Decision (unanimous) (30–27, 29–28, 29–28) | 3 | 5:00 |
| 2010-10-16 | UFC 120: Bisping vs. Akiyama | Lightweight | Spencer Fisher def. Curt Warburton | Decision (unanimous) (29–28, 29–28, 29–28) | 3 | 5:00 |
| 2010-06-19 | The Ultimate Fighter: Team Liddell vs. Team Ortiz Finale | Lightweight | Dennis Siver def. Spencer Fisher | Decision (unanimous) (30–27, 29–28, 29–28) | 3 | 5:00 |
| 2009-10-24 | UFC 104: Machida vs. Shogun | Lightweight | Joe Stevenson def. Spencer Fisher | TKO (punches) | 2 | 4:03 |
| 2009-06-13 | UFC 99: The Comeback | Lightweight | Spencer Fisher def. Caol Uno | Decision (unanimous) (29–28, 29–28, 29–28) | 3 | 5:00 |
| 2008-10-25 | UFC 90: Silva vs. Côté | Lightweight | Spencer Fisher def. Shannon Gugerty | Submission (triangle choke) | 3 | 3:56 |
| 2008-06-21 | The Ultimate Fighter: Team Rampage vs. Team Forrest Finale | Lightweight | Spencer Fisher def. Jeremy Stephens | Decision (unanimous) (29–28, 29–28, 29–28) | 3 | 5:00 |
| 2007-11-17 | UFC 78: Validation | Lightweight | Frankie Edgar def. Spencer Fisher | Decision (unanimous) (30–27, 30–27, 30–26) | 3 | 5:00 |
| 2007-06-12 | UFC Fight Night: Stout vs. Fisher | Lightweight | Spencer Fisher def. Sam Stout | Decision (unanimous) (30–27, 30–27, 30–27) | 3 | 5:00 |
| 2007-01-25 | UFC Fight Night: Evans vs. Salmon | Lightweight | Hermes França def. Spencer Fisher | TKO (punches) | 2 | 4:03 |
| 2006-10-14 | UFC 64: Unstoppable | Lightweight | Spencer Fisher def. Dan Lauzon | TKO (punches) | 1 | 4:38 |
| 2006-05-27 | UFC 60: Hughes vs. Gracie | Lightweight | Spencer Fisher def. Matt Wiman | KO (flying knee) | 2 | 1:43 |
| 2006-03-04 | UFC 58: USA vs. Canada | Lightweight | Sam Stout def. Spencer Fisher | Decision (split) (29–28, 29–28, 28–29) | 3 | 5:00 |
| 2006-01-16 | UFC Ultimate Fight Night 3 | Welterweight | Spencer Fisher def. Aaron Riley | TKO (doctor stoppage) | 1 | 5:00 |
| 2005-10-03 | UFC Ultimate Fight Night 2 | Welterweight | Spencer Fisher def. Thiago Alves | Submission (triangle choke) | 2 | 4:43 |