| 2022-10-01 | UFC Fight Night: Dern vs. Yan | Welterweight | Randy Brown def. Francisco Trinaldo | Decision (unanimous) (29–28, 29–28, 29–28) | 3 | 5:00 |
| 2022-05-07 | UFC 274: Oliveira vs. Gaethje | Welterweight | Francisco Trinaldo def. Danny Roberts | Decision (unanimous) (29–28, 30–27, 30–26) | 3 | 5:00 |
| 2021-10-23 | UFC Fight Night: Costa vs. Vettori | Welterweight | Francisco Trinaldo def. Dwight Grant | Decision (split) (29–27, 27–29, 29–27) | 3 | 5:00 |
| 2021-06-05 | UFC Fight Night: Rozenstruik vs. Sakai | Welterweight | Muslim Salikhov def. Francisco Trinaldo | Decision (unanimous) (30–27, 30–27, 30–27) | 3 | 5:00 |
| 2020-07-26 | UFC on ESPN: Whittaker vs. Till | Catchweight | Francisco Trinaldo def. Jai Herbert | TKO (punch) | 3 | 1:30 |
| 2020-03-14 | UFC Fight Night: Lee vs. Oliveira | Lightweight | Francisco Trinaldo def. John Makdessi | Decision (unanimous) (30–27, 30–27, 29–28) | 3 | 5:00 |
| 2019-11-16 | UFC Fight Night: Błachowicz vs. Jacaré | Lightweight | Francisco Trinaldo def. Bobby Green | Decision (unanimous) (30–27, 29–28, 29–28) | 3 | 5:00 |
| 2019-07-20 | UFC on ESPN: dos Anjos vs. Edwards | Lightweight | Alexander Hernandez def. Francisco Trinaldo | Decision (unanimous) (30–27, 30–27, 29–28) | 3 | 5:00 |
| 2018-09-22 | UFC Fight Night: Santos vs. Anders | Lightweight | Francisco Trinaldo def. Evan Dunham | KO (knee to the body) | 2 | 4:10 |
| 2018-02-18 | UFC Fight Night: Cowboy vs. Medeiros | Lightweight | James Vick def. Francisco Trinaldo | Decision (unanimous) (29–28, 29–28, 29–28) | 3 | 5:00 |
| 2017-10-28 | UFC Fight Night: Brunson vs. Machida | Lightweight | Francisco Trinaldo def. Jim Miller | Decision (unanimous) (29–28, 29–28, 29–28) | 3 | 5:00 |
| 2017-03-11 | UFC Fight Night: Belfort vs. Gastelum | Lightweight | Kevin Lee def. Francisco Trinaldo | Submission (rear-naked choke) | 2 | 3:12 |
| 2016-09-24 | UFC Fight Night: Cyborg vs. Länsberg | Lightweight | Francisco Trinaldo def. Paul Felder | TKO (doctor stoppage) | 3 | 2:25 |
| 2016-05-14 | UFC 198: Werdum vs. Miocic | Lightweight | Francisco Trinaldo def. Yancy Medeiros | Decision (unanimous) (29–26, 30–27, 30–26) | 3 | 5:00 |
| 2016-01-17 | UFC Fight Night: Dillashaw vs. Cruz | Lightweight | Francisco Trinaldo def. Ross Pearson | Decision (unanimous) (30–27, 29–28, 30–27) | 3 | 5:00 |
| 2015-08-23 | UFC Fight Night: Holloway vs. Oliveira | Lightweight | Francisco Trinaldo def. Chad Laprise | TKO (punches) | 1 | 2:43 |
| 2015-05-30 | UFC Fight Night: Condit vs. Alves | Lightweight | Francisco Trinaldo def. Norman Parke | Decision (split) (28–29, 29–28, 29–28) | 3 | 5:00 |
| 2015-03-21 | UFC Fight Night: Maia vs. LaFlare | Lightweight | Francisco Trinaldo def. Akbarh Arreola | Decision (unanimous) (30–27, 30–27, 30–27) | 3 | 5:00 |
| 2014-09-13 | UFC Fight Night: Bigfoot vs. Arlovski | Lightweight | Francisco Trinaldo def. Leandro Silva | Decision (unanimous) (29–28, 29–28, 29–28) | 3 | 5:00 |
| 2014-05-24 | UFC 173: Barão vs. Dillashaw | Lightweight | Michael Chiesa def. Francisco Trinaldo | Decision (unanimous) (30–26, 30–26, 30–27) | 3 | 5:00 |
| 2014-02-15 | UFC Fight Night: Machida vs. Mousasi | Lightweight | Francisco Trinaldo def. Jesse Ronson | Decision (split) (28–29, 29–28, 30–27) | 3 | 5:00 |
| 2013-09-04 | UFC Fight Night: Teixeira vs. Bader | Lightweight | Piotr Hallmann def. Francisco Trinaldo | Submission (kimura) | 2 | 3:50 |
| 2013-05-18 | UFC on FX: Belfort vs. Rockhold | Lightweight | Francisco Trinaldo def. Mike Rio | Submission (arm-triangle choke) | 1 | 3:08 |
| 2013-01-19 | UFC on FX: Belfort vs. Bisping | Lightweight | Francisco Trinaldo def. C.J. Keith | Submission (arm-triangle choke) | 2 | 1:50 |
| 2012-10-13 | UFC 153: Silva vs. Bonnar | Lightweight | Gleison Tibau def. Francisco Trinaldo | Decision (unanimous) (29–28, 29–28, 29–28) | 3 | 5:00 |
| 2012-06-23 | UFC 147: Silva vs. Franklin II | Middleweight | Francisco Trinaldo def. Delson Heleno | TKO (punches) | 1 | 4:21 |