| 2023-09-10 | UFC 293: Adesanya vs. Strickland | Lightweight | Jamie Mullarkey def. John Makdessi | Decision (unanimous) (29–28, 29–28, 29–28) | 3 | 5:00 |
| 2022-09-03 | UFC Fight Night: Gane vs. Tuivasa | Lightweight | Nasrat Haqparast def. John Makdessi | Decision (unanimous) (30–27, 30–27, 29–28) | 3 | 5:00 |
| 2021-04-10 | UFC on ABC: Vettori vs. Holland | Catchweight | John Makdessi def. Ignacio Bahamondes | Decision (split) (28–29, 29–28, 30–27) | 3 | 5:00 |
| 2020-03-14 | UFC Fight Night: Lee vs. Oliveira | Lightweight | Francisco Trinaldo def. John Makdessi | Decision (unanimous) (30–27, 30–27, 29–28) | 3 | 5:00 |
| 2019-03-23 | UFC Fight Night: Thompson vs. Pettis | Lightweight | John Makdessi def. Jesus Pinedo | Decision (unanimous) (30–27, 30–27, 29–28) | 3 | 5:00 |
| 2018-07-28 | UFC on Fox: Alvarez vs. Poirier 2 | Lightweight | John Makdessi def. Ross Pearson | Decision (unanimous) (30–26, 29–27, 29–28) | 3 | 5:00 |
| 2017-12-16 | UFC on Fox: Lawler vs. dos Anjos | Lightweight | John Makdessi def. Abel Trujillo | Decision (unanimous) (30–27, 30–27, 30–27) | 3 | 5:00 |
| 2016-12-10 | UFC 206: Holloway vs. Pettis | Lightweight | Lando Vannata def. John Makdessi | KO (wheel kick) | 1 | 1:40 |
| 2016-07-07 | UFC Fight Night: dos Anjos vs. Alvarez | Lightweight | John Makdessi def. Mehdi Baghdad | Decision (split) (28–29, 29–28, 29–28) | 3 | 5:00 |
| 2015-12-12 | UFC 194: Aldo vs. McGregor | Lightweight | Yancy Medeiros def. John Makdessi | Decision (split) (29–28, 28–29, 29–28) | 3 | 5:00 |
| 2015-05-23 | UFC 187: Johnson vs. Cormier | Lightweight | Donald Cerrone def. John Makdessi | TKO (head kick) | 2 | 4:44 |
| 2015-04-25 | UFC 186: Johnson vs. Horiguchi | Catchweight | John Makdessi def. Shane Campbell | TKO (punches) | 1 | 4:53 |
| 2014-02-01 | UFC 169: Barão vs. Faber 2 | Lightweight | Alan Patrick def. John Makdessi | Decision (unanimous) (29–28, 29–28, 30–27) | 3 | 5:00 |
| 2013-09-21 | UFC 165: Jones vs. Gustafsson | Lightweight | John Makdessi def. Renée Forte | KO (punches) | 1 | 2:01 |
| 2013-03-16 | UFC 158: St-Pierre vs. Diaz | Lightweight | John Makdessi def. Daron Cruickshank | Decision (unanimous) (29–28, 29–28, 29–28) | 3 | 5:00 |
| 2012-11-17 | UFC 154: St-Pierre vs. Condit | Lightweight | John Makdessi def. Sam Stout | Decision (unanimous) (30–27, 29–28, 30–27) | 3 | 5:00 |
| 2012-04-21 | UFC 145: Jones vs. Evans | Catchweight | Anthony Njokuani def. John Makdessi | Decision (unanimous) (30–27, 30–27, 30–27) | 3 | 5:00 |
| 2011-12-10 | UFC 140: Jones vs. Machida | Catchweight | Dennis Hallman def. John Makdessi | Submission (rear-naked choke) | 1 | 2:58 |
| 2011-04-30 | UFC 129: St-Pierre vs. Shields | Lightweight | John Makdessi def. Kyle Watson | KO (spinning back fist) | 3 | 1:27 |
| 2010-12-11 | UFC 124: St-Pierre vs. Koscheck 2 | Lightweight | John Makdessi def. Pat Audinwood | Decision (unanimous) (30–27, 30–27, 30–26) | 3 | 5:00 |