| 2019-02-17 | UFC on ESPN: Ngannou vs. Velasquez | Heavyweight | Francis Ngannou def. Cain Velasquez | KO (punches) | 1 | 0:26 |
| 2016-07-09 | UFC 200: Tate vs. Nunes | Heavyweight | Cain Velasquez def. Travis Browne | TKO (punches) | 1 | 4:57 |
| 2015-06-13 | UFC 188: Velasquez vs. Werdum | Heavyweight | Fabrício Werdum def. Cain Velasquez title | Submission (guillotine choke) | 3 | 2:13 |
| 2013-10-19 | UFC 166: Velasquez vs. dos Santos III | Heavyweight | Cain Velasquez def. Junior dos Santos title | TKO (slam and punch) | 5 | 3:09 |
| 2013-05-25 | UFC 160: Velasquez vs. Bigfoot 2 | Heavyweight | Cain Velasquez def. Antônio Silva title | TKO (punches) | 1 | 1:21 |
| 2012-12-29 | UFC 155: dos Santos vs. Velasquez 2 | Heavyweight | Cain Velasquez def. Junior dos Santos title | Decision (unanimous) (50–45, 50–43, 50–44) | 5 | 5:00 |
| 2012-05-26 | UFC 146: dos Santos vs. Mir | Heavyweight | Cain Velasquez def. Antônio Silva | TKO (punches) | 1 | 3:36 |
| 2011-11-12 | UFC on Fox: Velasquez vs. dos Santos | Heavyweight | Junior dos Santos def. Cain Velasquez title | KO (punches) | 1 | 1:04 |
| 2010-10-23 | UFC 121: Lesnar vs. Velasquez | Heavyweight | Cain Velasquez def. Brock Lesnar title | TKO (punches) | 1 | 4:12 |
| 2010-02-21 | UFC 110: Nogueira vs. Velasquez | Heavyweight | Cain Velasquez def. Antônio Rodrigo Nogueira | KO (punches) | 1 | 2:20 |
| 2009-10-24 | UFC 104: Machida vs. Shogun | Heavyweight | Cain Velasquez def. Ben Rothwell | TKO (punches) | 2 | 0:58 |
| 2009-06-13 | UFC 99: The Comeback | Heavyweight | Cain Velasquez def. Cheick Kongo | Decision (unanimous) (30–27, 30–27, 30–27) | 3 | 5:00 |
| 2009-02-07 | UFC Fight Night: Lauzon vs. Stephens | Heavyweight | Cain Velasquez def. Denis Stojnić | TKO (punches) | 2 | 2:34 |
| 2008-07-19 | UFC Fight Night: Silva vs. Irvin | Heavyweight | Cain Velasquez def. Jake O'Brien | TKO (punches) | 1 | 2:02 |
| 2008-04-19 | UFC 83: Serra vs. St-Pierre 2 | Heavyweight | Cain Velasquez def. Brad Morris | TKO (punches) | 1 | 2:10 |