| 2025-07-19 | UFC 318: Holloway vs. Poirier 3 | Lightweight | Max Holloway def. Dustin Poirier title | Decision (unanimous) (48–47, 49–46, 49–46) | 5 | 5:00 |
| 2024-06-01 | UFC 302: Makhachev vs. Poirier | Lightweight | Islam Makhachev def. Dustin Poirier title | Submission (brabo choke) | 5 | 2:42 |
| 2024-03-09 | UFC 299: O'Malley vs. Vera 2 | Lightweight | Dustin Poirier def. Benoît Saint Denis | KO (punches) | 2 | 2:32 |
| 2023-07-29 | UFC 291: Poirier vs. Gaethje 2 | Lightweight | Justin Gaethje def. Dustin Poirier | KO (head kick) | 2 | 1:00 |
| 2022-11-12 | UFC 281: Adesanya vs. Pereira | Lightweight | Dustin Poirier def. Michael Chandler | Submission (rear-naked choke) | 3 | 2:00 |
| 2021-12-11 | UFC 269: Oliveira vs. Poirier | Lightweight | Charles Oliveira def. Dustin Poirier title | Submission (rear-naked choke) | 3 | 1:02 |
| 2021-07-10 | UFC 264: Poirier vs. McGregor 3 | Lightweight | Dustin Poirier def. Conor McGregor | TKO (doctor stoppage) | 1 | 5:00 |
| 2021-01-24 | UFC 257: Poirier vs. McGregor 2 | Lightweight | Dustin Poirier def. Conor McGregor | TKO (punches) | 2 | 2:32 |
| 2020-06-27 | UFC on ESPN: Poirier vs. Hooker | Lightweight | Dustin Poirier def. Dan Hooker | Decision (unanimous) (48–47, 48–47, 48–46) | 5 | 5:00 |
| 2019-09-07 | UFC 242: Khabib vs. Poirier | Lightweight | Khabib Nurmagomedov def. Dustin Poirier title | Submission (rear-naked choke) | 3 | 2:06 |
| 2019-04-13 | UFC 236: Holloway vs. Poirier 2 | Lightweight | Dustin Poirier def. Max Holloway title | Decision (unanimous) (49–46, 49–46, 49–46) | 5 | 5:00 |
| 2018-07-28 | UFC on Fox: Alvarez vs. Poirier 2 | Lightweight | Dustin Poirier def. Eddie Alvarez | TKO (punches) | 2 | 4:05 |
| 2018-04-14 | UFC on Fox: Poirier vs. Gaethje | Lightweight | Dustin Poirier def. Justin Gaethje | TKO (punches) | 4 | 0:33 |
| 2017-11-11 | UFC Fight Night: Poirier vs. Pettis | Lightweight | Dustin Poirier def. Anthony Pettis | Submission (body triangle) | 3 | 2:08 |
| 2017-05-13 | UFC 211: Miocic vs. dos Santos 2 | Lightweight | Eddie Alvarez vs. Dustin Poirier | No Contest (illegal knees) | 2 | 4:12 |
| 2017-02-11 | UFC 208: Holm vs. de Randamie | Lightweight | Dustin Poirier def. Jim Miller | Decision (majority) (28–28, 30–27, 29–28) | 3 | 5:00 |
| 2016-09-17 | UFC Fight Night: Poirier vs. Johnson | Lightweight | Michael Johnson def. Dustin Poirier | KO (punches) | 1 | 1:35 |
| 2016-06-04 | UFC 199: Rockhold vs. Bisping 2 | Lightweight | Dustin Poirier def. Bobby Green | KO (punches) | 1 | 2:53 |
| 2016-01-02 | UFC 195: Lawler vs. Condit | Lightweight | Dustin Poirier def. Joseph Duffy | Decision (unanimous) (30–26, 30–27, 30–27) | 3 | 5:00 |
| 2015-06-06 | UFC Fight Night: Boetsch vs. Henderson | Catchweight | Dustin Poirier def. Yancy Medeiros | TKO (body kick and punches) | 1 | 2:38 |
| 2015-04-04 | UFC Fight Night: Mendes vs. Lamas | Lightweight | Dustin Poirier def. Carlos Diego Ferreira | KO (punches) | 1 | 3:45 |
| 2014-09-27 | UFC 178: Johnson vs. Cariaso | Featherweight | Conor McGregor def. Dustin Poirier | TKO (punches) | 1 | 1:46 |
| 2014-04-16 | The Ultimate Fighter Nations Finale: Bisping vs. Kennedy | Featherweight | Dustin Poirier def. Akira Corassani | TKO (punches) | 2 | 0:42 |
| 2013-12-28 | UFC 168: Weidman vs. Silva 2 | Catchweight | Dustin Poirier def. Diego Brandao | KO (punches) | 1 | 4:54 |
| 2013-08-31 | UFC 164: Henderson vs. Pettis 2 | Featherweight | Dustin Poirier def. Erik Koch | Decision (unanimous) (29–28, 29–27, 29–27) | 3 | 5:00 |
| 2013-02-16 | UFC on Fuel TV: Barão vs. McDonald | Featherweight | Cub Swanson def. Dustin Poirier | Decision (unanimous) (29–28, 30–27, 30–27) | 3 | 5:00 |
| 2012-12-15 | The Ultimate Fighter: Team Carwin vs. Team Nelson Finale | Featherweight | Dustin Poirier def. Jonathan Brookins | Submission (D'Arce choke) | 1 | 4:15 |
| 2012-05-15 | UFC on Fuel TV: The Korean Zombie vs. Poirier | Featherweight | Chan Sung Jung def. Dustin Poirier | Technical Submission (D'Arce choke) | 4 | 1:07 |
| 2012-02-04 | UFC 143: Diaz vs. Condit | Featherweight | Dustin Poirier def. Max Holloway | Submission (triangle armbar) | 1 | 3:23 |
| 2011-11-12 | UFC on Fox: Velasquez vs. dos Santos | Featherweight | Dustin Poirier def. Pablo Garza | Submission (D'Arce choke) | 2 | 1:32 |
| 2011-06-11 | UFC 131: dos Santos vs. Carwin | Featherweight | Dustin Poirier def. Jason Young | Decision (unanimous) (30–27, 30–27, 29–28) | 3 | 5:00 |
| 2011-01-01 | UFC 125: Resolution | Featherweight | Dustin Poirier def. Josh Grispi | Decision (unanimous) (30–27, 30–27, 30–27) | 3 | 5:00 |