| 2014-03-08 | UFC Fight Night: Gustafsson vs. Manuwa | Lightweight | Michael Johnson def. Melvin Guillard | Decision (unanimous) (30–27, 30–27, 29–28) | 3 | 5:00 |
| 2013-10-26 | UFC Fight Night: Machida vs. Muñoz | Lightweight | Ross Pearson vs. Melvin Guillard | No Contest (illegal knee) | 1 | 1:57 |
| 2013-07-27 | UFC on Fox: Johnson vs. Moraga | Lightweight | Melvin Guillard def. Mac Danzig | KO (punches) | 2 | 2:47 |
| 2012-12-29 | UFC 155: dos Santos vs. Velasquez 2 | Lightweight | Jamie Varner def. Melvin Guillard | Decision (split) (30–27, 27–30, 30–27) | 3 | 5:00 |
| 2012-08-11 | UFC 150: Henderson vs. Edgar II | Catchweight | Donald Cerrone def. Melvin Guillard | KO (head kick and punch) | 1 | 1:16 |
| 2012-07-07 | UFC 148: Silva vs. Sonnen II | Lightweight | Melvin Guillard def. Fabricio Camoes | Decision (unanimous) (30–27, 30–27, 30–27) | 3 | 5:00 |
| 2012-01-20 | UFC on FX: Guillard vs. Miller | Lightweight | Jim Miller def. Melvin Guillard | Submission (rear-naked choke) | 1 | 3:04 |
| 2011-10-08 | UFC 136: Edgar vs. Maynard III | Lightweight | Joe Lauzon def. Melvin Guillard | Submission (rear-naked choke) | 1 | 0:47 |
| 2011-07-02 | UFC 132: Cruz vs. Faber | Lightweight | Melvin Guillard def. Shane Roller | KO (punches) | 1 | 2:12 |
| 2011-01-22 | UFC: Fight for the Troops 2 | Lightweight | Melvin Guillard def. Evan Dunham | TKO (knees) | 1 | 2:58 |
| 2010-09-25 | UFC 119: Mir vs. Cro Cop | Lightweight | Melvin Guillard def. Jeremy Stephens | Decision (split) (28–29, 29–28, 30–27) | 3 | 5:00 |
| 2010-05-29 | UFC 114: Rampage vs. Evans | Lightweight | Melvin Guillard def. Waylon Lowe | TKO (knee to the body) | 1 | 3:28 |
| 2010-02-06 | UFC 109: Relentless | Lightweight | Melvin Guillard def. Ronys Torres | Decision (unanimous) (29–28, 29–28, 29–28) | 3 | 5:00 |
| 2009-09-16 | UFC Fight Night: Diaz vs. Guillard | Lightweight | Nate Diaz def. Melvin Guillard | Submission (guillotine choke) | 2 | 2:13 |
| 2009-06-20 | The Ultimate Fighter: United States vs. United Kingdom Finale | Lightweight | Melvin Guillard def. Gleison Tibau | Decision (split) (29–28, 28–29, 29–28) | 3 | 5:00 |
| 2008-07-05 | UFC 86: Jackson vs. Griffin | Lightweight | Melvin Guillard def. Dennis Siver | TKO (punches) | 1 | 0:36 |
| 2007-12-29 | UFC 79: Nemesis | Lightweight | Rich Clementi def. Melvin Guillard | Submission (rear-naked choke) | 1 | 4:40 |
| 2007-04-05 | UFC Fight Night: Stevenson vs. Guillard | Lightweight | Joe Stevenson def. Melvin Guillard | Submission (guillotine choke) | 1 | 0:27 |
| 2006-09-23 | UFC 63: Hughes vs. Penn | Lightweight | Melvin Guillard def. Gabe Ruediger | TKO (punch to the body) | 2 | 1:01 |
| 2006-05-27 | UFC 60: Hughes vs. Gracie | Lightweight | Melvin Guillard def. Rick Davis | KO (punch) | 1 | 1:37 |
| 2006-01-16 | UFC Ultimate Fight Night 3 | Welterweight | Josh Neer def. Melvin Guillard | Submission (triangle choke) | 1 | 4:20 |
| 2005-11-05 | The Ultimate Fighter: Team Hughes vs. Team Franklin Finale | Welterweight | Melvin Guillard def. Marcus Davis | TKO (doctor stoppage) | 2 | 2:55 |