| 2013-10-19 | UFC 166: Velasquez vs. dos Santos III | Lightweight | K. J. Noons def. George Sotiropoulos | Decision (unanimous) (29–28, 29–28, 30–27) | 3 | 5:00 |
| 2012-12-15 | UFC on FX: Sotiropoulos vs. Pearson | Lightweight | Ross Pearson def. George Sotiropoulos | TKO (punches) | 3 | 0:41 |
| 2011-07-02 | UFC 132: Cruz vs. Faber | Lightweight | Rafael dos Anjos def. George Sotiropoulos | KO (punch) | 1 | 0:59 |
| 2011-02-27 | UFC 127: Penn vs. Fitch | Lightweight | Dennis Siver def. George Sotiropoulos | Decision (unanimous) (29–28, 30–28, 30–27) | 3 | 5:00 |
| 2010-11-20 | UFC 123: Rampage vs. Machida | Lightweight | George Sotiropoulos def. Joe Lauzon | Submission (kimura) | 2 | 2:43 |
| 2010-07-03 | UFC 116: Lesnar vs. Carwin | Lightweight | George Sotiropoulos def. Kurt Pellegrino | Decision (unanimous) (30–27, 30–27, 29–28) | 3 | 5:00 |
| 2010-02-21 | UFC 110: Nogueira vs. Velasquez | Lightweight | George Sotiropoulos def. Joe Stevenson | Decision (unanimous) (30–27, 30–27, 30–27) | 3 | 5:00 |
| 2009-11-21 | UFC 106: Ortiz vs. Griffin 2 | Lightweight | George Sotiropoulos def. Jason Dent | Submission (armbar) | 2 | 4:36 |
| 2009-08-08 | UFC 101: Declaration | Lightweight | George Sotiropoulos def. George Roop | Submission (kimura) | 2 | 1:59 |
| 2008-04-02 | UFC Fight Night: Florian vs. Lauzon | Welterweight | George Sotiropoulos def. Roman Mitichyan | TKO (punches) | 2 | 2:24 |
| 2007-12-08 | The Ultimate Fighter: Team Hughes vs. Team Serra Finale | Welterweight | George Sotiropoulos def. Billy Miles | Submission (rear-naked choke) | 1 | 1:36 |