| 2026-05-02 | UFC Fight Night: Della Maddalena vs. Prates | Welterweight | Carlos Prates def. Jack Della Maddalena | TKO (leg kicks and elbows) | 3 | 3:17 |
| 2025-11-15 | UFC 322: Della Maddalena vs. Makhachev | Welterweight | Islam Makhachev def. Jack Della Maddalena title | Decision (unanimous) (50–45, 50–45, 50–45) | 5 | 5:00 |
| 2025-05-10 | UFC 315: Muhammad vs. Della Maddalena | Welterweight | Jack Della Maddalena def. Belal Muhammad title | Decision (unanimous) (48–47, 48–47, 49–46) | 5 | 5:00 |
| 2024-03-09 | UFC 299: O'Malley vs. Vera 2 | Welterweight | Jack Della Maddalena def. Gilbert Burns | KO (knee and elbows) | 3 | 3:43 |
| 2023-09-16 | UFC Fight Night: Grasso vs. Shevchenko 2 | Welterweight | Jack Della Maddalena def. Kevin Holland | Decision (split) (28–29, 29–28, 29–28) | 3 | 5:00 |
| 2023-07-15 | UFC on ESPN: Holm vs. Bueno Silva | Welterweight | Jack Della Maddalena def. Bassil Hafez | Decision (split) (28–29, 29–28, 29–28) | 3 | 5:00 |
| 2023-02-12 | UFC 284: Makhachev vs. Volkanovski | Welterweight | Jack Della Maddalena def. Randy Brown | Submission (rear-naked choke) | 1 | 2:13 |
| 2022-11-19 | UFC Fight Night: Nzechukwu vs. Cuțelaba | Welterweight | Jack Della Maddalena def. Danny Roberts | TKO (punches) | 1 | 3:24 |
| 2022-06-12 | UFC 275: Teixeira vs. Procházka | Welterweight | Jack Della Maddalena def. Ramazan Emeev | TKO (punches) | 1 | 2:32 |
| 2022-01-22 | UFC 270: Ngannou vs. Gane | Welterweight | Jack Della Maddalena def. Pete Rodriguez | TKO (punches) | 1 | 2:59 |