| 2016-09-10 | UFC 203: Miocic vs. Overeem | Welterweight | Yancy Medeiros def. Sean Spencer | Submission (rear-naked choke) | 2 | 0:49 |
| 2016-02-06 | UFC Fight Night: Hendricks vs. Thompson | Welterweight | Mike Pyle def. Sean Spencer | TKO (elbows and knees) | 3 | 4:25 |
| 2015-01-18 | UFC Fight Night: McGregor vs. Siver | Welterweight | Cathal Pendred def. Sean Spencer | Decision (unanimous) (29–28, 30–27, 30–27) | 3 | 5:00 |
| 2014-09-13 | UFC Fight Night: Bigfoot vs. Arlovski | Welterweight | Sean Spencer def. Paulo Thiago | Decision (unanimous) (30–27, 30–27, 30–27) | 3 | 5:00 |
| 2014-03-15 | UFC 171: Hendricks vs. Lawler | Welterweight | Alex Garcia def. Sean Spencer | Decision (split) (29–28, 28–29, 30–27) | 3 | 5:00 |
| 2013-11-30 | The Ultimate Fighter: Team Rousey vs. Team Tate Finale | Welterweight | Sean Spencer def. Drew Dober | Decision (unanimous) (30–27, 30–27, 30–27) | 3 | 5:00 |
| 2013-09-04 | UFC Fight Night: Teixeira vs. Bader | Welterweight | Sean Spencer def. Yuri Villefort | Decision (split) (30–27, 28–29, 29–28) | 3 | 5:00 |
| 2013-01-26 | UFC on Fox: Johnson vs. Dodson | Middleweight | Rafael Natal def. Sean Spencer | Submission (arm-triangle choke) | 3 | 2:13 |