| 2026-09-05 | UFC Fight Night: Hooker vs. Parnasse | Heavyweight | Mario Pinto def. Ryan Spann | TKO (punches) | 2 | 0:55 |
| 2026-04-25 | UFC Fight Night: Sterling vs. Zalal | Heavyweight | Ryan Spann def. Marcus Buchecha | KO (punches) | 2 | 2:10 |
| 2025-07-19 | UFC 318: Holloway vs. Poirier 3 | Heavyweight | Ryan Spann def. Łukasz Brzeski | Submission (guillotine choke) | 1 | 2:37 |
| 2025-03-15 | UFC Fight Night: Vettori vs. Dolidze 2 | Heavyweight | Waldo Cortes-Acosta def. Ryan Spann | KO (punches) | 2 | 4:48 |
| 2024-10-05 | UFC 307: Pereira vs. Rountree Jr. | Light Heavyweight | Ryan Spann def. Ovince Saint Preux | Submission (guillotine choke) | 1 | 1:35 |
| 2024-04-27 | UFC on ESPN: Nicolau vs. Perez | Light Heavyweight | Bogdan Guskov def. Ryan Spann | TKO (punches) | 2 | 3:16 |
| 2023-08-26 | UFC Fight Night: Holloway vs. The Korean Zombie | Light Heavyweight | Anthony Smith def. Ryan Spann | Decision (split) (28–29, 29–28, 29–28) | 3 | 5:00 |
| 2023-03-11 | UFC Fight Night: Yan vs. Dvalishvili | Catchweight | Nikita Krylov def. Ryan Spann | Submission (triangle choke) | 1 | 3:38 |
| 2022-11-12 | UFC 281: Adesanya vs. Pereira | Catchweight | Ryan Spann def. Dominick Reyes | KO (punches) | 1 | 1:20 |
| 2022-05-14 | UFC on ESPN: Błachowicz vs. Rakić | Light Heavyweight | Ryan Spann def. Ion Cuțelaba | Submission (guillotine choke) | 1 | 2:22 |
| 2021-09-18 | UFC Fight Night: Smith vs. Spann | Light Heavyweight | Anthony Smith def. Ryan Spann | Submission (rear-naked choke) | 1 | 3:47 |
| 2021-03-13 | UFC Fight Night: Edwards vs. Muhammad | Light Heavyweight | Ryan Spann def. Misha Cirkunov | TKO (punches) | 1 | 1:11 |
| 2020-09-19 | UFC Fight Night: Covington vs. Woodley | Light Heavyweight | Johnny Walker def. Ryan Spann | KO (elbows and punches) | 1 | 2:43 |
| 2020-05-09 | UFC 249: Ferguson vs. Gaethje | Light Heavyweight | Ryan Spann def. Sam Alvey | Decision (split) (29–28, 28–29, 29–28) | 3 | 5:00 |
| 2019-10-12 | UFC Fight Night: Joanna vs. Waterson | Light Heavyweight | Ryan Spann def. Devin Clark | Submission (guillotine choke) | 2 | 2:01 |
| 2019-05-11 | UFC 237: Namajunas vs. Andrade | Light Heavyweight | Ryan Spann def. Antônio Rogério Nogueira | KO (punches) | 1 | 2:07 |
| 2018-09-22 | UFC Fight Night: Santos vs. Anders | Light Heavyweight | Ryan Spann def. Luis Henrique | Decision (unanimous) (30–27, 30–27, 29–28) | 3 | 5:00 |