| 2022-02-12 | UFC 271: Adesanya vs. Whittaker 2 | Women’s Flyweight | Casey O'Neill def. Roxanne Modafferi | Decision (split) (29–28, 28–29, 29–28) | 3 | 5:00 |
| 2021-09-25 | UFC 266: Volkanovski vs. Ortega | Women’s Flyweight | Taila Santos def. Roxanne Modafferi | Decision (unanimous) (30–27, 30–27, 30–27) | 3 | 5:00 |
| 2021-01-20 | UFC on ESPN: Chiesa vs. Magny | Women’s Flyweight | Viviane Araújo def. Roxanne Modafferi | Decision (unanimous) (30–27, 30–27, 30–26) | 3 | 5:00 |
| 2020-09-12 | UFC Fight Night: Waterson vs. Hill | Women’s Flyweight | Roxanne Modafferi def. Andrea Lee | Decision (unanimous) (29–28, 29–28, 29–28) | 3 | 5:00 |
| 2020-06-20 | UFC on ESPN: Blaydes vs. Volkov | Women’s Flyweight | Lauren Murphy def. Roxanne Modafferi | Decision (unanimous) (30–27, 30–27, 29–28) | 3 | 5:00 |
| 2020-01-18 | UFC 246: McGregor vs. Cowboy | Women’s Flyweight | Roxanne Modafferi def. Maycee Barber | Decision (unanimous) (30–27, 30–27, 30–26) | 3 | 5:00 |
| 2019-07-20 | UFC on ESPN: dos Anjos vs. Edwards | Catchweight | Jennifer Maia def. Roxanne Modafferi | Decision (unanimous) (30–27, 30–27, 30–27) | 3 | 5:00 |
| 2019-04-20 | UFC Fight Night: Overeem vs. Oleinik | Women’s Flyweight | Roxanne Modafferi def. Antonina Shevchenko | Decision (split) (29–28, 28–29, 29–28) | 3 | 5:00 |
| 2018-11-03 | UFC 230: Cormier vs. Lewis | Catchweight | Sijara Eubanks def. Roxanne Modafferi | Decision (unanimous) (30–27, 30–27, 30–27) | 3 | 5:00 |
| 2018-07-06 | The Ultimate Fighter: Undefeated Finale | Women’s Flyweight | Roxanne Modafferi def. Barb Honchak | TKO (elbows) | 2 | 3:32 |
| 2017-12-01 | The Ultimate Fighter: A New World Champion Finale | Women’s Flyweight | Nicco Montaño def. Roxanne Modafferi title | Decision (unanimous) (50–45, 49–46, 49–46) | 5 | 5:00 |
| 2013-11-30 | The Ultimate Fighter: Team Rousey vs. Team Tate Finale | Women’s Bantamweight | Raquel Pennington def. Roxanne Modafferi | Decision (unanimous) (30–27, 30–27, 29–28) | 3 | 5:00 |