| 2025-07-12 | UFC on ESPN: Lewis vs. Teixeira | Women’s Flyweight | Eduarda Moura def. Lauren Murphy | Decision (unanimous) (29–28, 29–28, 29–28) | 3 | 5:00 |
| 2023-01-21 | UFC 283: Teixeira vs. Hill | Women’s Flyweight | Jéssica Andrade def. Lauren Murphy | Decision (unanimous) (30–25, 30–25, 30–26) | 3 | 5:00 |
| 2022-07-16 | UFC on ABC: Ortega vs. Rodríguez | Women’s Flyweight | Lauren Murphy def. Miesha Tate | Decision (unanimous) (30–27, 30–27, 29–28) | 3 | 5:00 |
| 2021-09-25 | UFC 266: Volkanovski vs. Ortega | Women’s Flyweight | Valentina Shevchenko def. Lauren Murphy title | TKO (elbows and punches) | 4 | 4:00 |
| 2021-06-12 | UFC 263: Adesanya vs. Vettori 2 | Women’s Flyweight | Lauren Murphy def. Joanne Calderwood | Decision (split) (29–28, 28–29, 29–28) | 3 | 5:00 |
| 2020-10-24 | UFC 254: Khabib vs. Gaethje | Women’s Flyweight | Lauren Murphy def. Liliya Shakirova | Submission (rear-naked choke) | 2 | 3:31 |
| 2020-06-20 | UFC on ESPN: Blaydes vs. Volkov | Women’s Flyweight | Lauren Murphy def. Roxanne Modafferi | Decision (unanimous) (30–27, 30–27, 29–28) | 3 | 5:00 |
| 2020-02-08 | UFC 247: Jones vs. Reyes | Women’s Flyweight | Lauren Murphy def. Andrea Lee | Decision (split) (28–29, 29–28, 30–27) | 3 | 5:00 |
| 2019-08-03 | UFC on ESPN: Covington vs. Lawler | Women’s Flyweight | Lauren Murphy def. Mara Romero Borella | TKO (knee and elbows) | 3 | 1:46 |
| 2018-06-01 | UFC Fight Night: Rivera vs. Moraes | Women’s Flyweight | Sijara Eubanks def. Lauren Murphy | Decision (unanimous) (30–27, 30–27, 29–28) | 3 | 5:00 |
| 2017-12-01 | The Ultimate Fighter: A New World Champion Finale | Women’s Flyweight | Lauren Murphy def. Barb Honchak | Decision (split) (29–28, 28–29, 29–28) | 3 | 5:00 |
| 2016-07-13 | UFC Fight Night: McDonald vs. Lineker | Women’s Bantamweight | Katlyn Chookagian def. Lauren Murphy | Decision (unanimous) (29–28, 29–28, 29–28) | 3 | 5:00 |
| 2016-02-21 | UFC Fight Night: Cowboy vs. Cowboy | Women’s Bantamweight | Lauren Murphy def. Kelly Faszholz | TKO (elbows and punches) | 3 | 4:55 |
| 2015-04-04 | UFC Fight Night: Mendes vs. Lamas | Women’s Bantamweight | Liz Carmouche def. Lauren Murphy | Decision (unanimous) (29–28, 29–28, 29–28) | 3 | 5:00 |
| 2014-08-16 | UFC Fight Night: Bader vs. Saint Preux | Women’s Bantamweight | Sara McMann def. Lauren Murphy | Decision (split) (28–29, 29–28, 29–28) | 3 | 5:00 |