| 2026-07-25 | UFC Fight Night: Ankalaev vs. Guskov | Welterweight | Sam Patterson def. Santiago Ponzinibbio | TKO (punches) | 2 | 3:06 |
| 2025-05-03 | UFC on ESPN: Sandhagen vs. Figueiredo | Welterweight | Daniel Rodriguez def. Santiago Ponzinibbio | TKO (punches) | 3 | 1:12 |
| 2025-01-11 | UFC Fight Night: Dern vs. Ribas 2 | Welterweight | Santiago Ponzinibbio def. Carlston Harris | TKO (punches) | 3 | 3:13 |
| 2024-07-13 | UFC on ESPN: Namajunas vs. Cortez | Welterweight | Muslim Salikhov def. Santiago Ponzinibbio | Decision (split) (28–29, 29–28, 29–28) | 3 | 5:00 |
| 2023-04-08 | UFC 287: Pereira vs. Adesanya 2 | Welterweight | Kevin Holland def. Santiago Ponzinibbio | KO (punch) | 3 | 3:16 |
| 2022-12-10 | UFC 282: Błachowicz vs. Ankalaev | Catchweight | Santiago Ponzinibbio def. Alex Morono | KO (punches) | 3 | 2:29 |
| 2022-05-21 | UFC Fight Night: Holm vs. Vieira | Welterweight | Michel Pereira def. Santiago Ponzinibbio | Decision (split) (28–29, 30–27, 29–28) | 3 | 5:00 |
| 2021-12-11 | UFC 269: Oliveira vs. Poirier | Welterweight | Geoff Neal def. Santiago Ponzinibbio | Decision (split) (28–29, 30–27, 29–28) | 3 | 5:00 |
| 2021-06-05 | UFC Fight Night: Rozenstruik vs. Sakai | Welterweight | Santiago Ponzinibbio def. Miguel Baeza | Decision (unanimous) (29–28, 29–28, 29–28) | 3 | 5:00 |
| 2021-01-16 | UFC on ABC: Holloway vs. Kattar | Welterweight | Li Jingliang def. Santiago Ponzinibbio | KO (punch) | 1 | 4:25 |
| 2018-11-17 | UFC Fight Night: Magny vs. Ponzinibbio | Welterweight | Santiago Ponzinibbio def. Neil Magny | KO (punch) | 4 | 2:36 |
| 2017-12-16 | UFC on Fox: Lawler vs. dos Anjos | Welterweight | Santiago Ponzinibbio def. Mike Perry | Decision (unanimous) (29–28, 29–28, 29–28) | 3 | 5:00 |
| 2017-07-16 | UFC Fight Night: Nelson vs. Ponzinibbio | Welterweight | Santiago Ponzinibbio def. Gunnar Nelson | KO (punches) | 1 | 1:22 |
| 2017-02-19 | UFC Fight Night: Lewis vs. Browne | Welterweight | Santiago Ponzinibbio def. Nordine Taleb | Decision (unanimous) (29–28, 29–28, 29–28) | 3 | 5:00 |
| 2016-08-06 | UFC Fight Night: Rodríguez vs. Caceres | Welterweight | Santiago Ponzinibbio def. Zak Cummings | Decision (unanimous) (29–28, 29–28, 30–27) | 3 | 5:00 |
| 2016-04-16 | UFC on Fox: Teixeira vs. Evans | Welterweight | Santiago Ponzinibbio def. Court McGee | TKO (punches) | 1 | 4:15 |
| 2015-12-10 | UFC Fight Night: Namajunas vs. VanZant | Welterweight | Santiago Ponzinibbio def. Andreas Ståhl | TKO (punches) | 1 | 4:25 |
| 2015-06-27 | UFC Fight Night: Machida vs. Romero | Welterweight | Lorenz Larkin def. Santiago Ponzinibbio | TKO (punches) | 2 | 3:07 |
| 2015-02-22 | UFC Fight Night: Bigfoot vs. Mir | Welterweight | Santiago Ponzinibbio def. Sean Strickland | Decision (unanimous) (30–27, 30–27, 30–27) | 3 | 5:00 |
| 2014-09-13 | UFC Fight Night: Bigfoot vs. Arlovski | Welterweight | Santiago Ponzinibbio def. Wendell Oliveira | TKO (punches) | 1 | 1:20 |
| 2013-11-09 | UFC Fight Night: Belfort vs. Henderson 2 | Welterweight | Ryan LaFlare def. Santiago Ponzinibbio | Decision (unanimous) (30–27, 30–27, 30–27) | 3 | 5:00 |