| 2024-11-09 | UFC Fight Night: Magny vs. Prates | Welterweight | Charles Radtke def. Matthew Semelsberger | TKO (punches) | 1 | 0:51 |
| 2024-01-13 | UFC Fight Night: Ankalaev vs. Walker 2 | Welterweight | Preston Parsons def. Matthew Semelsberger | Decision (unanimous) (30–27, 30–27, 30–27) | 3 | 5:00 |
| 2023-07-29 | UFC 291: Poirier vs. Gaethje 2 | Welterweight | Uroš Medić def. Matthew Semelsberger | TKO (spinning backfist and punches) | 3 | 2:36 |
| 2023-04-22 | UFC Fight Night: Pavlovich vs. Blaydes | Welterweight | Jeremiah Wells def. Matthew Semelsberger | Decision (split) (30–27, 28–29, 30–27) | 3 | 5:00 |
| 2022-12-17 | UFC Fight Night: Cannonier vs. Strickland | Welterweight | Matthew Semelsberger def. Jake Matthews | Decision (unanimous) (30–27, 29–28, 29–28) | 3 | 5:00 |
| 2022-07-30 | UFC 277: Peña vs. Nunes 2 | Welterweight | Alex Morono def. Matthew Semelsberger | Decision (unanimous) (29–28, 29–28, 30–27) | 3 | 5:00 |
| 2022-03-12 | UFC Fight Night: Santos vs. Ankalaev | Welterweight | Matthew Semelsberger def. A.J. Fletcher | Decision (unanimous) (29–28, 29–28, 29–28) | 3 | 5:00 |
| 2021-09-25 | UFC 266: Volkanovski vs. Ortega | Welterweight | Matthew Semelsberger def. Martin Sano Jr. | KO (punch) | 1 | 0:15 |
| 2021-06-19 | UFC on ESPN: The Korean Zombie vs. Ige | Welterweight | Khaos Williams def. Matthew Semelsberger | Decision (unanimous) (30–27, 29–28, 29–28) | 3 | 5:00 |
| 2021-03-13 | UFC Fight Night: Edwards vs. Muhammad | Welterweight | Matthew Semelsberger def. Jason Witt | KO (punch) | 1 | 0:16 |
| 2020-08-22 | UFC on ESPN: Munhoz vs. Edgar | Welterweight | Matthew Semelsberger def. Carlton Minus | Decision (unanimous) (30–26, 30–27, 29–28) | 3 | 5:00 |