| 2025-05-03 | UFC on ESPN: Sandhagen vs. Figueiredo | Heavyweight | Thomas Petersen def. Don'Tale Mayes | Decision (unanimous) (30–25, 30–26, 30–26) | 3 | 5:00 |
| 2025-02-15 | UFC Fight Night: Cannonier vs. Rodrigues | Heavyweight | Valter Walker def. Don'Tale Mayes | Submission (heel hook) | 1 | 1:17 |
| 2024-08-03 | UFC on ABC: Sandhagen vs. Nurmagomedov | Heavyweight | Shamil Gaziev def. Don'Tale Mayes | Decision (unanimous) (30–27, 30–27, 30–27) | 3 | 5:00 |
| 2024-04-27 | UFC on ESPN: Nicolau vs. Perez | Heavyweight | Don'Tale Mayes def. Caio Machado | Decision (unanimous) (29–28, 29–28, 29–28) | 3 | 5:00 |
| 2023-11-04 | UFC Fight Night: Almeida vs. Lewis | Heavyweight | Rodrigo Nascimento def. Don'Tale Mayes | Decision (unanimous) (30–27, 29–28, 29–28) | 3 | 5:00 |
| 2023-06-03 | UFC on ESPN: Kara-France vs. Albazi | Heavyweight | Don'Tale Mayes def. Andrei Arlovski | TKO (punches) | 2 | 3:17 |
| 2023-02-25 | UFC Fight Night: Muniz vs. Allen | Heavyweight | Augusto Sakai def. Don'Tale Mayes | Decision (unanimous) (30–27, 30–27, 30–27) | 3 | 5:00 |
| 2022-07-30 | UFC 277: Peña vs. Nunes 2 | Heavyweight | Hamdy Abdelwahab vs. Don'Tale Mayes | No Contest (overturned) | 3 | 5:00 |
| 2021-12-18 | UFC Fight Night: Lewis vs. Daukaus | Heavyweight | Don'Tale Mayes def. Josh Parisian | TKO (elbows) | 3 | 3:26 |
| 2020-11-14 | UFC Fight Night: Felder vs. dos Anjos | Heavyweight | Don'Tale Mayes def. Roque Martinez | Decision (unanimous) (30–27, 30–27, 29–28) | 3 | 5:00 |
| 2020-05-16 | UFC on ESPN: Overeem vs. Harris | Heavyweight | Rodrigo Nascimento def. Don'Tale Mayes | Submission (rear-naked choke) | 2 | 2:05 |
| 2019-10-26 | UFC Fight Night: Maia vs. Askren | Heavyweight | Ciryl Gane def. Don'Tale Mayes | Submission (heel hook) | 3 | 4:46 |