| 2021-03-27 | UFC 260: Miocic vs. Ngannou 2 | Welterweight | Vicente Luque def. Tyron Woodley | Submission (brabo choke) | 1 | 3:56 |
| 2020-09-19 | UFC Fight Night: Covington vs. Woodley | Welterweight | Colby Covington def. Tyron Woodley | TKO (rib injury) | 5 | 1:19 |
| 2020-05-30 | UFC on ESPN: Woodley vs. Burns | Welterweight | Gilbert Burns def. Tyron Woodley | Decision (unanimous) (50–45, 50–44, 50–44) | 5 | 5:00 |
| 2019-03-02 | UFC 235: Jones vs. Smith | Welterweight | Kamaru Usman def. Tyron Woodley title | Decision (unanimous) (50–44, 50–44, 50–45) | 5 | 5:00 |
| 2018-09-08 | UFC 228: Woodley vs. Till | Welterweight | Tyron Woodley def. Darren Till title | Submission (brabo choke) | 2 | 4:19 |
| 2017-07-29 | UFC 214: Cormier vs. Jones 2 | Welterweight | Tyron Woodley def. Demian Maia title | Decision (unanimous) (50–45, 49–46, 49–46) | 5 | 5:00 |
| 2017-03-04 | UFC 209: Woodley vs. Thompson 2 | Welterweight | Tyron Woodley def. Stephen Thompson title | Decision (majority) (48–47, 47–47, 48–47) | 5 | 5:00 |
| 2016-11-12 | UFC 205: Alvarez vs. McGregor | Welterweight | Tyron Woodley vs. Stephen Thompson title | Draw (majority) (47–47, 47–47, 48–47) | 5 | 5:00 |
| 2016-07-30 | UFC 201: Lawler vs. Woodley | Welterweight | Tyron Woodley def. Robbie Lawler title | KO (punches) | 1 | 2:12 |
| 2015-01-31 | UFC 183: Silva vs. Diaz | Catchweight | Tyron Woodley def. Kelvin Gastelum | Decision (split) (28–29, 29–28, 30–27) | 3 | 5:00 |
| 2014-08-23 | UFC Fight Night: Bisping vs. Le | Welterweight | Tyron Woodley def. Kim Dong-hyun | TKO (punches) | 1 | 1:01 |
| 2014-06-14 | UFC 174: Johnson vs. Bagautinov | Welterweight | Rory MacDonald def. Tyron Woodley | Decision (unanimous) (30–27, 30–27, 30–27) | 3 | 5:00 |
| 2014-03-15 | UFC 171: Hendricks vs. Lawler | Welterweight | Tyron Woodley def. Carlos Condit | TKO (knee injury) | 2 | 2:00 |
| 2013-11-16 | UFC 167: St-Pierre vs. Hendricks | Welterweight | Tyron Woodley def. Josh Koscheck | KO (punches) | 1 | 4:38 |
| 2013-06-15 | UFC 161: Evans vs. Henderson | Welterweight | Jake Shields def. Tyron Woodley | Decision (split) (27–30, 29–28, 29–28) | 3 | 5:00 |
| 2013-02-02 | UFC 156: Aldo vs. Edgar | Welterweight | Tyron Woodley def. Jay Hieron | KO (punches) | 1 | 0:36 |