| 2026-06-14 | UFC Freedom 250 | Bantamweight | Sean O'Malley def. Aiemann Zahabi | TKO (punches) | 2 | 4:02 |
| 2026-01-24 | UFC 324: Gaethje vs. Pimblett | Bantamweight | Sean O'Malley def. Song Yadong | Decision (unanimous) (29–28, 29–28, 29–28) | 3 | 5:00 |
| 2025-06-07 | UFC 316: Dvalishvili vs. O'Malley 2 | Bantamweight | Merab Dvalishvili def. Sean O'Malley title | Submission (north-south choke) | 3 | 4:42 |
| 2024-09-14 | UFC 306: O'Malley vs. Dvalishvili | Bantamweight | Merab Dvalishvili def. Sean O'Malley title | Decision (unanimous) (49–46, 48–47, 48–47) | 5 | 5:00 |
| 2024-03-09 | UFC 299: O'Malley vs. Vera 2 | Bantamweight | Sean O'Malley def. Marlon Vera title | Decision (unanimous) (50–45, 50–45, 50–44) | 5 | 5:00 |
| 2023-08-19 | UFC 292: Sterling vs. O'Malley | Bantamweight | Sean O'Malley def. Aljamain Sterling title | TKO (punches) | 2 | 0:51 |
| 2022-10-22 | UFC 280: Oliveira vs. Makhachev | Bantamweight | Sean O'Malley def. Petr Yan | Decision (split) (29–28, 28–29, 29–28) | 3 | 5:00 |
| 2022-07-02 | UFC 276: Adesanya vs. Cannonier | Bantamweight | Pedro Munhoz vs. Sean O'Malley | No Contest (accidental eye poke) | 2 | 3:09 |
| 2021-12-11 | UFC 269: Oliveira vs. Poirier | Bantamweight | Sean O'Malley def. Raulian Paiva | TKO (punches) | 1 | 4:42 |
| 2021-07-10 | UFC 264: Poirier vs. McGregor 3 | Bantamweight | Sean O'Malley def. Kris Moutinho | TKO (punches) | 3 | 4:33 |
| 2021-03-27 | UFC 260: Miocic vs. Ngannou 2 | Bantamweight | Sean O'Malley def. Thomas Almeida | KO (punches) | 3 | 3:52 |
| 2020-08-15 | UFC 252: Miocic vs. Cormier 3 | Bantamweight | Marlon Vera def. Sean O'Malley | TKO (elbows and punches) | 1 | 4:40 |
| 2020-06-06 | UFC 250: Nunes vs. Spencer | Bantamweight | Sean O'Malley def. Eddie Wineland | KO (punch) | 1 | 1:54 |
| 2020-03-07 | UFC 248: Adesanya vs. Romero | Bantamweight | Sean O'Malley def. José Alberto Quiñónez | TKO (head kick and punches) | 1 | 2:02 |
| 2018-03-03 | UFC 222: Cyborg vs. Kunitskaya | Bantamweight | Sean O'Malley def. Andre Soukhamthath | Decision (unanimous) (29–27, 29–27, 29–28) | 3 | 5:00 |
| 2017-12-01 | The Ultimate Fighter: A New World Champion Finale | Bantamweight | Sean O'Malley def. Terrion Ware | Decision (unanimous) (29–28, 29–28, 29–28) | 3 | 5:00 |