| 2026-03-14 | UFC Fight Night: Emmett vs. Vallejos | Women’s Strawweight | Piera Rodríguez def. Sam Hughes | Decision (unanimous) (30–27, 30–27, 30–27) | 3 | 5:00 |
| 2025-09-06 | UFC Fight Night: Imavov vs. Borralho | Women’s Strawweight | Sam Hughes def. Shauna Bannon | Submission (rear-naked choke) | 2 | 1:58 |
| 2025-03-15 | UFC Fight Night: Vettori vs. Dolidze 2 | Women’s Strawweight | Sam Hughes def. Stephanie Luciano | Decision (split) (29–28, 28–29, 29–27) | 3 | 5:00 |
| 2024-08-03 | UFC on ABC: Sandhagen vs. Nurmagomedov | Women’s Strawweight | Sam Hughes def. Victoria Dudakova | Decision (split) (27–30, 29–28, 29–28) | 3 | 5:00 |
| 2024-02-24 | UFC Fight Night: Moreno vs. Royval 2 | Women’s Strawweight | Yazmin Jauregui def. Sam Hughes | Decision (unanimous) (30–27, 30–27, 30–27) | 3 | 5:00 |
| 2023-04-08 | UFC 287: Pereira vs. Adesanya 2 | Women’s Strawweight | Sam Hughes def. Jaqueline Amorim | Decision (unanimous) (29–28, 29–28, 29–28) | 3 | 5:00 |
| 2022-10-15 | UFC Fight Night: Grasso vs. Araújo | Women’s Strawweight | Piera Rodríguez def. Sam Hughes | Decision (unanimous) (29–28, 29–28, 29–28) | 3 | 5:00 |
| 2022-05-21 | UFC Fight Night: Holm vs. Vieira | Women’s Strawweight | Sam Hughes def. Elise Reed | TKO (elbow and punches) | 3 | 3:52 |
| 2022-04-16 | UFC on ESPN: Luque vs. Muhammad 2 | Women’s Strawweight | Sam Hughes def. Istela Nunes | Decision (majority) (29–27, 29–27, 28–28) | 3 | 5:00 |
| 2021-11-20 | UFC Fight Night: Vieira vs. Tate | Women’s Strawweight | Luana Pinheiro def. Sam Hughes | Decision (unanimous) (30–27, 30–27, 29–28) | 3 | 5:00 |
| 2021-05-01 | UFC on ESPN: Reyes vs. Procházka | Women’s Strawweight | Loma Lookboonmee def. Sam Hughes | Decision (unanimous) (29–28, 29–28, 29–28) | 3 | 5:00 |
| 2020-12-12 | UFC 256: Figueiredo vs. Moreno | Women’s Strawweight | Tecia Torres def. Sam Hughes | TKO (doctor stoppage) | 1 | 5:00 |