| 2015-12-11 | The Ultimate Fighter: Team McGregor vs. Team Faber Finale | Welterweight | Ryan LaFlare def. Mike Pierce | Decision (unanimous) (30–27, 29–28, 29–28) | 3 | 5:00 |
| 2013-10-09 | UFC Fight Night: Maia vs. Shields | Welterweight | Rousimar Palhares def. Mike Pierce | Submission (heel hook) | 1 | 0:31 |
| 2013-07-06 | UFC 162: Silva vs. Weidman | Welterweight | Mike Pierce def. David Mitchell | TKO (punches) | 2 | 2:55 |
| 2012-12-15 | UFC on FX: Sotiropoulos vs. Pearson | Welterweight | Mike Pierce def. Seth Baczynski | Decision (unanimous) (30–27, 29–28, 29–28) | 3 | 5:00 |
| 2012-10-05 | UFC on FX: Browne vs. Bigfoot | Welterweight | Mike Pierce def. Aaron Simpson | KO (punches) | 2 | 0:29 |
| 2012-06-08 | UFC on FX: Johnson vs. McCall 2 | Welterweight | Mike Pierce def. Carlos Eduardo Rocha | Decision (unanimous) (30–27, 30–27, 30–27) | 3 | 5:00 |
| 2012-02-04 | UFC 143: Diaz vs. Condit | Welterweight | Josh Koscheck def. Mike Pierce | Decision (split) (28–29, 29–28, 29–28) | 3 | 5:00 |
| 2011-11-12 | UFC on Fox: Velasquez vs. dos Santos | Welterweight | Mike Pierce def. Paul Bradley | Decision (split) (28–29, 30–27, 29–28) | 3 | 5:00 |
| 2011-08-06 | UFC 133: Evans vs. Ortiz | Welterweight | Johny Hendricks def. Mike Pierce | Decision (split) (28–29, 29–28, 29–28) | 3 | 5:00 |
| 2011-02-05 | UFC 126: Silva vs. Belfort | Welterweight | Mike Pierce def. Kenny Robertson | KO (punches) | 2 | 0:29 |
| 2010-08-28 | UFC 118: Edgar vs. Penn 2 | Welterweight | Mike Pierce def. Amilcar Alves | Submission (cross-body armbar) | 3 | 3:11 |
| 2010-03-21 | UFC Live: Vera vs. Jones | Welterweight | Mike Pierce def. Julio Paulino | Decision (unanimous) (30–27, 30–27, 30–27) | 3 | 5:00 |
| 2009-12-12 | UFC 107: Penn vs. Sanchez | Welterweight | Jon Fitch def. Mike Pierce | Decision (unanimous) (29–28, 29–28, 29–28) | 3 | 5:00 |
| 2009-09-16 | UFC Fight Night: Diaz vs. Guillard | Welterweight | Mike Pierce def. Brock Larson | Decision (unanimous) (30–27, 30–27, 30–27) | 3 | 5:00 |