| 2026-03-21 | UFC Fight Night: Evloev vs. Murphy | Featherweight | Movsar Evloev def. Lerone Murphy | Decision (majority) (48–46, 48–46, 47–47) | 5 | 5:00 |
| 2025-08-16 | UFC 319: du Plessis vs. Chimaev | Featherweight | Lerone Murphy def. Aaron Pico | KO (spinning back elbow) | 1 | 3:21 |
| 2025-04-05 | UFC on ESPN: Emmett vs. Murphy | Featherweight | Lerone Murphy def. Josh Emmett | Decision (unanimous) (48–47, 48–47, 49–46) | 5 | 5:00 |
| 2024-10-26 | UFC 308: Topuria vs. Holloway | Featherweight | Lerone Murphy def. Dan Ige | Decision (unanimous) (29–28, 29–28, 29–28) | 3 | 5:00 |
| 2024-05-18 | UFC Fight Night: Barboza vs. Murphy | Featherweight | Lerone Murphy def. Edson Barboza | Decision (unanimous) (49–46, 50–45, 50–45) | 5 | 5:00 |
| 2023-07-22 | UFC Fight Night: Aspinall vs. Tybura | Featherweight | Lerone Murphy def. Joshua Culibao | Decision (unanimous) (30–26, 30–26, 30–27) | 3 | 5:00 |
| 2023-03-18 | UFC 286: Edwards vs. Usman 3 | Featherweight | Lerone Murphy def. Gabriel Santos | Decision (split) (28–29, 29–28, 29–28) | 3 | 5:00 |
| 2021-10-30 | UFC 267: Błachowicz vs. Teixeira | Featherweight | Lerone Murphy def. Makwan Amirkhani | KO (knee) | 2 | 0:14 |
| 2021-01-20 | UFC on ESPN: Chiesa vs. Magny | Featherweight | Lerone Murphy def. Douglas Silva de Andrade | Decision (unanimous) (29–28, 29–28, 30–27) | 3 | 5:00 |
| 2020-07-16 | UFC on ESPN: Kattar vs. Ige | Featherweight | Lerone Murphy def. Ricardo Ramos | TKO (punches) | 1 | 4:18 |
| 2019-09-07 | UFC 242: Khabib vs. Poirier | Featherweight | Zubaira Tukhugov vs. Lerone Murphy | Draw (split) (28–29, 29–28, 28–28) | 3 | 5:00 |