| 2012-05-15 | UFC on Fuel TV: The Korean Zombie vs. Poirier | Middleweight | Tom Lawlor def. Jason MacDonald | KO (punch) | 1 | 0:50 |
| 2011-09-17 | UFC Fight Night: Shields vs. Ellenberger | Middleweight | Alan Belcher def. Jason MacDonald | TKO (submission to strikes) | 1 | 3:48 |
| 2011-04-30 | UFC 129: St-Pierre vs. Shields | Middleweight | Jason MacDonald def. Ryan Jensen | Submission (triangle choke) | 1 | 1:37 |
| 2010-05-08 | UFC 113: Machida vs. Shogun 2 | Middleweight | John Salter def. Jason MacDonald | TKO (ankle injury) | 1 | 2:42 |
| 2009-04-18 | UFC 97: Redemption | Middleweight | Nate Quarry def. Jason MacDonald | TKO (elbows) | 1 | 2:27 |
| 2008-12-13 | The Ultimate Fighter: Team Nogueira vs. Team Mir Finale | Catchweight | Wilson Gouveia def. Jason MacDonald | TKO (submission to strikes) | 1 | 2:18 |
| 2008-09-06 | UFC 88: Breakthrough | Middleweight | Jason MacDonald def. Jason Lambert | Submission (rear-naked choke) | 2 | 1:20 |
| 2008-08-09 | UFC 87: Seek and Destroy | Middleweight | Demian Maia def. Jason MacDonald | Submission (rear-naked choke) | 3 | 2:44 |
| 2008-04-19 | UFC 83: Serra vs. St-Pierre 2 | Middleweight | Jason MacDonald def. Joe Doerksen | TKO (elbows) | 2 | 0:56 |
| 2007-10-20 | UFC 77: Hostile Territory | Middleweight | Yushin Okami def. Jason MacDonald | Decision (unanimous) (30–27, 30–27, 30–27) | 3 | 5:00 |
| 2007-06-16 | UFC 72: Victory | Middleweight | Jason MacDonald def. Rory Singer | TKO (punches and elbows) | 2 | 3:18 |
| 2007-03-03 | UFC 68: The Uprising | Middleweight | Rich Franklin def. Jason MacDonald | TKO (corner stoppage) | 2 | 5:00 |
| 2006-12-30 | UFC 66: Liddell vs. Ortiz | Middleweight | Jason MacDonald def. Chris Leben | Submission (guillotine choke) | 2 | 4:03 |
| 2006-10-10 | UFC Fight Night 6.5 | Middleweight | Jason MacDonald def. Ed Herman | Submission (triangle choke) | 1 | 2:43 |