| 2020-10-18 | UFC Fight Night: Ortega vs. The Korean Zombie | Welterweight | James Krause def. Cláudio Silva | Decision (unanimous) (30–27, 30–27, 30–27) | 3 | 5:00 |
| 2020-02-08 | UFC 247: Jones vs. Reyes | Middleweight | Trevin Giles def. James Krause | Decision (split) (28–29, 29–28, 29–28) | 3 | 5:00 |
| 2019-11-16 | UFC Fight Night: Błachowicz vs. Jacaré | Welterweight | James Krause def. Sérgio Moraes | KO (punches) | 3 | 4:19 |
| 2018-08-25 | UFC Fight Night: Gaethje vs. Vick | Welterweight | James Krause def. Warlley Alves | KO (knee and punches) | 2 | 2:28 |
| 2018-01-14 | UFC Fight Night: Stephens vs. Choi | Lightweight | James Krause def. Alex White | Decision (unanimous) (29–28, 29–28, 29–28) | 3 | 5:00 |
| 2017-07-07 | The Ultimate Fighter: Redemption Finale | Welterweight | James Krause def. Tom Gallicchio | Decision (unanimous) (30–27, 30–27, 30–27) | 3 | 5:00 |
| 2016-02-21 | UFC Fight Night: Cowboy vs. Cowboy | Lightweight | James Krause def. Shane Campbell | Decision (unanimous) (29–28, 29–28, 29–28) | 3 | 5:00 |
| 2015-07-25 | UFC on Fox: Dillashaw vs. Barão 2 | Lightweight | James Krause def. Daron Cruickshank | Submission (rear-naked choke) | 1 | 1:27 |
| 2015-02-28 | UFC 184: Rousey vs. Zingano | Lightweight | Valmir Lazaro def. James Krause | Decision (split) (29–28, 28–29, 29–28) | 3 | 5:00 |
| 2014-09-27 | UFC 178: Johnson vs. Cariaso | Lightweight | Jorge Masvidal def. James Krause | Decision (unanimous) (30–27, 29–28, 30–27) | 3 | 5:00 |
| 2014-05-24 | UFC 173: Barão vs. Dillashaw | Lightweight | James Krause def. Jamie Varner | TKO (ankle injury) | 1 | 5:00 |
| 2013-11-06 | UFC: Fight for the Troops 3 | Lightweight | Bobby Green def. James Krause | TKO (body kick) | 1 | 3:50 |
| 2013-06-15 | UFC 161: Evans vs. Henderson | Lightweight | James Krause def. Sam Stout | Submission (guillotine choke) | 3 | 4:47 |