| 2022-09-03 | UFC Fight Night: Gane vs. Tuivasa | Middleweight | Roman Kopylov def. Alessio Di Chirico | KO (punches) | 3 | 1:09 |
| 2021-08-28 | UFC on ESPN: Barboza vs. Chikadze | Middleweight | Abdul Razak Alhassan def. Alessio Di Chirico | KO (head kick) | 1 | 0:17 |
| 2021-01-16 | UFC on ABC: Holloway vs. Kattar | Middleweight | Alessio Di Chirico def. Joaquin Buckley | KO (head kick) | 1 | 2:12 |
| 2020-08-29 | UFC Fight Night: Smith vs. Rakić | Middleweight | Zak Cummings def. Alessio Di Chirico | Decision (unanimous) (29–28, 29–28, 30–27) | 3 | 5:00 |
| 2019-09-28 | UFC Fight Night: Hermansson vs. Cannonier | Middleweight | Makhmud Muradov def. Alessio Di Chirico | Decision (unanimous) (29–28, 29–28, 29–28) | 3 | 5:00 |
| 2019-06-22 | UFC Fight Night: Moicano vs. The Korean Zombie | Middleweight | Kevin Holland def. Alessio Di Chirico | Decision (unanimous) (29–28, 29–28, 29–28) | 3 | 5:00 |
| 2018-07-06 | The Ultimate Fighter: Undefeated Finale | Catchweight | Alessio Di Chirico def. Julian Marquez | Decision (split) (27–30, 29–28, 29–28) | 3 | 5:00 |
| 2017-12-16 | UFC on Fox: Lawler vs. dos Anjos | Middleweight | Alessio Di Chirico def. Oluwale Bamgbose | KO (knee) | 2 | 2:14 |
| 2017-01-28 | UFC on Fox: Shevchenko vs. Peña | Middleweight | Eric Spicely def. Alessio Di Chirico | Submission (triangle choke) | 1 | 2:14 |
| 2016-08-27 | UFC on Fox: Maia vs. Condit | Middleweight | Alessio Di Chirico def. Garreth McLellan | Decision (split) (29–28, 28–29, 29–28) | 3 | 5:00 |
| 2016-04-10 | UFC Fight Night: Rothwell vs. dos Santos | Middleweight | Bojan Veličković def. Alessio Di Chirico | Decision (unanimous) (29–28, 29–28, 30–27) | 3 | 5:00 |