| 2020 | 2020-02-17 | Delray Beach | ATP doubles | Hard | Bob Bryan / Mike Bryan | Luke Bambridge / Ben Mclachlan | 3-6 7-5 (10-5) |
| 2019 | 2019-03-18 | Miami | ATP doubles | Hard | Bob Bryan / Mike Bryan | Wesley Koolhof / Stefanos Tsitsipas | 7-5 7-6(8) |
| 2019 | 2019-02-18 | Delray Beach | ATP doubles | Hard | Bob Bryan / Mike Bryan | Ken Skupski / Neal Skupski | 7-6(5) 6-4 |
| 2018 | 2018-04-16 | Monte Carlo | ATP doubles | Clay | Bob Bryan / Mike Bryan | Oliver Marach / Mate Pavic | 7-6(5) 6-3 |
| 2018 | 2018-03-19 | Miami | ATP doubles | Hard | Bob Bryan / Mike Bryan | Karen Khachanov / Andrey Rublev | 4-6 7-6(5) (10-4) |
| 2017 | 2017-07-24 | Atlanta | ATP doubles | Hard | Bob Bryan / Mike Bryan | Wesley Koolhof / Artem Sitak | 6-3 6-4 |
| 2017 | 2017-06-26 | Eastbourne | ATP doubles | Grass | Bob Bryan / Mike Bryan | Rohan Bopanna / Andre Sa | 6-7(4) 6-4 (10-3) |
| 2016 | 2016-05-09 | Rome | ATP doubles | Clay | Bob Bryan / Mike Bryan | Vasek Pospisil / Jack Sock | 2-6 6-3 (10-7) |
| 2016 | 2016-04-18 | Barcelona | ATP doubles | Clay | Bob Bryan / Mike Bryan | Pablo Cuevas / Marcel Granollers | 7-5 7-5 |
| 2016 | 2016-04-04 | Houston | ATP doubles | Clay | Bob Bryan / Mike Bryan | Victor Estrella / Santiago Gonzalez | 4-6 6-3 (10-8) |
| 2015 | 2015-08-10 | Canada | ATP doubles | Hard | Bob Bryan / Mike Bryan | Daniel Nestor / Edouard Roger-Vasselin | 7-6 3-6 10-6 |
| 2015 | 2015-08-03 | Washington | ATP doubles | Hard | Bob Bryan / Mike Bryan | Ivan Dodig / Marcelo Melo | 6-4 6-2 |
| 2015 | 2015-07-27 | Atlanta | ATP doubles | Hard | Bob Bryan / Mike Bryan | Colin Fleming / Gilles Muller | 4-6 7-6 10-4 |
| 2015 | 2015-04-12 | Monte Carlo | ATP doubles | Clay | Bob Bryan / Mike Bryan | Simone Bolelli / Fabio Fognini | 7-6 6-1 |
| 2015 | 2015-03-25 | Miami | ATP doubles | Hard | Bob Bryan / Mike Bryan | Vasek Pospisil / Jack Sock | 6-3 1-6 10-8 |
| 2015 | 2015-02-16 | Delray Beach | ATP doubles | Hard | Bob Bryan / Mike Bryan | Raven Klaasen / Leander Paes | 6-3 3-6 10-6 |
| 2014 | 2014-11-09 | Tour Finals | ATP doubles | Hard | Bob Bryan / Mike Bryan | Ivan Dodig / Marcelo Melo | 6-7 6-2 10-7 |
| 2014 | 2014-10-27 | Paris | ATP doubles | Hard | Bob Bryan / Mike Bryan | Marcin Matkowski / Jurgen Melzer | 7-6 5-7 10-6 |
| 2014 | 2014-10-05 | Shanghai | ATP doubles | Hard | Bob Bryan / Mike Bryan | Julien Benneteau / Edouard Roger-Vasselin | 6-3 7-6 |
| 2014 | 2014-08-25 | US Open | ATP doubles | Hard | Bob Bryan / Mike Bryan | Marcel Granollers / Marc Lopez | 6-3 6-4 |
| 2014 | 2014-08-10 | Cincinnati | ATP doubles | Hard | Bob Bryan / Mike Bryan | Vasek Pospisil / Jack Sock | 6-3 6-2 |
| 2014 | 2014-04-13 | Monte Carlo | ATP doubles | Clay | Bob Bryan / Mike Bryan | Ivan Dodig / Marcelo Melo | 6-3 3-6 10-8 |
| 2014 | 2014-04-07 | Houston | ATP doubles | Clay | Bob Bryan / Mike Bryan | David Marrero / Fernando Verdasco | 4-6 6-4 11-9 |
| 2014 | 2014-03-19 | Miami | ATP doubles | Hard | Bob Bryan / Mike Bryan | Juan Sebastian Cabal / Robert Farah | 7-6 6-4 |
| 2014 | 2014-03-06 | Indian Wells | ATP doubles | Hard | Bob Bryan / Mike Bryan | Alexander Peya / Bruno Soares | 6-4 6-3 |
| 2014 | 2014-02-17 | Delray Beach | ATP doubles | Hard | Bob Bryan / Mike Bryan | Frantisek Cermak / Mikhail Elgin | 6-2 6-3 |
| 2013 | 2013-10-28 | Paris | ATP doubles | Hard | Bob Bryan / Mike Bryan | Alexander Peya / Bruno Soares | 6-3 6-3 |
| 2013 | 2013-08-11 | Cincinnati | ATP doubles | Hard | Bob Bryan / Mike Bryan | Marcel Granollers / Marc Lopez | 6-4 4-6 10-4 |
| 2013 | 2013-06-24 | Wimbledon | ATP doubles | Grass | Bob Bryan / Mike Bryan | Ivan Dodig / Marcelo Melo | 3-6 6-3 6-4 6-4 |
| 2013 | 2013-06-10 | Queen's Club | ATP doubles | Grass | Bob Bryan / Mike Bryan | Alexander Peya / Bruno Soares | 4-6 7-5 10-3 |
| 2013 | 2013-05-27 | Roland-Garros | ATP doubles | Clay | Bob Bryan / Mike Bryan | Michael Llodra / Nicolas Mahut | 6-4 4-6 7-6 |
| 2013 | 2013-05-12 | Rome | ATP doubles | Clay | Bob Bryan / Mike Bryan | Mahesh Bhupathi / Rohan Bopanna | 6-2 6-3 |
| 2013 | 2013-05-05 | Madrid | ATP doubles | Clay | Bob Bryan / Mike Bryan | Alexander Peya / Bruno Soares | 6-2 6-3 |
| 2013 | 2013-03-07 | Indian Wells | ATP doubles | Hard | Bob Bryan / Mike Bryan | Treat Conrad Huey / Jerzy Janowicz | 6-3 3-6 10-6 |
| 2013 | 2013-02-18 | Memphis | ATP doubles | Hard | Bob Bryan / Mike Bryan | James Blake / Jack Sock | 6-1 6-2 |
| 2013 | 2013-01-14 | Australian Open | ATP doubles | Hard | Bob Bryan / Mike Bryan | Robin Haase / Igor Sijsling | 6-3 6-4 |
| 2013 | 2013-01-07 | Sydney | ATP doubles | Hard | Bob Bryan / Mike Bryan | Max Mirnyi / Horia Tecau | 6-4 6-4 |
| 2012 | 2012-10-01 | Beijing | ATP doubles | Hard | Bob Bryan / Mike Bryan | Carlos Berlocq / Denis Istomin | 6-3 6-2 |
| 2012 | 2012-08-27 | US Open | ATP doubles | Hard | Bob Bryan / Mike Bryan | Leander Paes / Radek Stepanek | 6-3 6-4 |
| 2012 | 2012-08-06 | Canada | ATP doubles | Hard | Bob Bryan / Mike Bryan | Marcel Granollers / Marc Lopez | 6-1 4-6 12-10 |
| 2012 | 2012-07-25 | London Olympics | ATP doubles | Grass | Bob Bryan / Mike Bryan | Michael Llodra / Jo-Wilfried Tsonga | 6-4 7-6 |
| 2012 | 2012-05-20 | Nice | ATP doubles | Clay | Bob Bryan / Mike Bryan | Oliver Marach / Filip Polasek | 7-6 6-3 |
| 2012 | 2012-04-15 | Monte Carlo | ATP doubles | Clay | Bob Bryan / Mike Bryan | Max Mirnyi / Daniel Nestor | 6-2 6-3 |
| 2012 | 2012-01-09 | Sydney | ATP doubles | Hard | Bob Bryan / Mike Bryan | Matthew Ebden / Jarkko Nieminen | 6-1 6-4 |
| 2011 | 2011-10-31 | Valencia | ATP doubles | Hard | Bob Bryan / Mike Bryan | Eric Butorac / Jean Julien Rojer | 6-4 7-6 |
| 2011 | 2011-10-24 | Vienna | ATP doubles | Hard | Bob Bryan / Mike Bryan | Max Mirnyi / Daniel Nestor | 7-6 6-3 |
| 2011 | 2011-06-20 | Wimbledon | ATP doubles | Grass | Bob Bryan / Mike Bryan | Robert Lindstedt / Horia Tecau | 6-3 6-4 7-6 |
| 2011 | 2011-06-06 | Queen's Club | ATP doubles | Grass | Bob Bryan / Mike Bryan | Mahesh Bhupathi / Leander Paes | 6-7 7-6 10-6 |
| 2011 | 2011-05-01 | Madrid | ATP doubles | Clay | Bob Bryan / Mike Bryan | Michael Llodra / Nenad Zimonjic | 6-3 6-3 |
| 2011 | 2011-04-10 | Monte Carlo | ATP doubles | Clay | Bob Bryan / Mike Bryan | Juan Ignacio Chela / Bruno Soares | 6-3 6-2 |
| 2011 | 2011-04-04 | Houston | ATP doubles | Clay | Bob Bryan / Mike Bryan | John Isner / Sam Querrey | 6-7 6-2 10-5 |
| 2011 | 2011-01-17 | Australian Open | ATP doubles | Hard | Bob Bryan / Mike Bryan | Mahesh Bhupathi / Leander Paes | 6-3 6-4 |
| 2010 | 2010-11-01 | Basel | ATP doubles | Hard | Bob Bryan / Mike Bryan | Daniel Nestor / Nenad Zimonjic | 6-3 3-6 10-3 |
| 2010 | 2010-10-04 | Beijing | ATP doubles | Hard | Bob Bryan / Mike Bryan | Mariusz Fyrstenberg / Marcin Matkowski | 6-1 7-6 |
| 2010 | 2010-08-30 | US Open | ATP doubles | Hard | Bob Bryan / Mike Bryan | Rohan Bopanna / Aisam Ul Haq Qureshi | 7-6 7-6 |
| 2010 | 2010-08-15 | Cincinnati | ATP doubles | Hard | Bob Bryan / Mike Bryan | Mahesh Bhupathi / Max Mirnyi | 6-3 6-4 |
| 2010 | 2010-08-09 | Canada | ATP doubles | Hard | Bob Bryan / Mike Bryan | Julien Benneteau / Michael Llodra | 7-5 6-3 |
| 2010 | 2010-07-26 | Los Angeles | ATP doubles | Hard | Bob Bryan / Mike Bryan | Eric Butorac / Jean Julien Rojer | 6-7 6-2 10-7 |
| 2010 | 2010-05-16 | Dusseldorf | ATP doubles | Clay | Bob Bryan / Mike Bryan | Eduardo Schwank / Horacio Zeballos | 6-1 6-2 |
| 2010 | 2010-05-09 | Madrid | ATP doubles | Clay | Bob Bryan / Mike Bryan | Daniel Nestor / Nenad Zimonjic | 6-3 6-4 |
| 2010 | 2010-04-25 | Rome | ATP doubles | Clay | Bob Bryan / Mike Bryan | John Isner / Sam Querrey | 6-2 6-3 |
| 2010 | 2010-04-05 | Houston | ATP doubles | Clay | Bob Bryan / Mike Bryan | Stephen Huss / Wesley Moodie | 6-3 7-5 |
| 2010 | 2010-02-22 | Delray Beach | ATP doubles | Hard | Bob Bryan / Mike Bryan | Philipp Marx / Igor Zelenay | 6-3 7-6 |
| 2010 | 2010-01-18 | Australian Open | ATP doubles | Hard | Bob Bryan / Mike Bryan | Daniel Nestor / Nenad Zimonjic | 6-3 6-7 6-3 |
| 2009 | 2009-11-22 | Tour Finals | ATP doubles | Hard | Bob Bryan / Mike Bryan | Max Mirnyi / Andy Ram | 7-6 6-3 |
| 2009 | 2009-10-05 | Beijing | ATP doubles | Hard | Bob Bryan / Mike Bryan | Mark Knowles / Andy Roddick | 6-4 6-2 |
| 2009 | 2009-07-27 | Los Angeles | ATP doubles | Hard | Bob Bryan / Mike Bryan | Benjamin Becker / Frank Moser | 6-4 7-6 |
| 2009 | 2009-04-06 | Houston | ATP doubles | Clay | Bob Bryan / Mike Bryan | Jesse Levine / Ryan Sweeting | 6-1 6-2 |
| 2009 | 2009-02-23 | Delray Beach | ATP doubles | Hard | Bob Bryan / Mike Bryan | Marcelo Melo / Andre Sa | 6-4 6-4 |
| 2009 | 2009-01-19 | Australian Open | ATP doubles | Hard | Bob Bryan / Mike Bryan | Mahesh Bhupathi / Mark Knowles | 2-6 7-5 6-0 |
| 2009 | 2009-01-12 | Sydney | ATP doubles | Hard | Bob Bryan / Mike Bryan | Daniel Nestor / Nenad Zimonjic | 6-1 7-6 |
| 2008 | 2008-08-25 | US Open | ATP doubles | Hard | Bob Bryan / Mike Bryan | Lukas Dlouhy / Leander Paes | 7-6 7-6 |
| 2008 | 2008-07-28 | Cincinnati | ATP doubles | Hard | Bob Bryan / Mike Bryan | Jonathan Erlich / Andy Ram | 4-6 7-6 10-7 |
| 2008 | 2008-05-05 | Rome | ATP doubles | Clay | Bob Bryan / Mike Bryan | Daniel Nestor / Nenad Zimonjic | 3-6 6-4 10-8 |
| 2008 | 2008-04-28 | Barcelona | ATP doubles | Clay | Bob Bryan / Mike Bryan | Mariusz Fyrstenberg / Marcin Matkowski | 6-3 6-2 |
| 2008 | 2008-03-27 | Miami | ATP doubles | Hard | Bob Bryan / Mike Bryan | Mahesh Bhupathi / Mark Knowles | 6-2 6-2 |
| 2008 | | Wimbledon | Mixed doubles | Grass | Bob Bryan / Samantha Stosur | — | |
| 2007 | 2007-10-28 | Paris | ATP doubles | Hard | Bob Bryan / Mike Bryan | Daniel Nestor / Nenad Zimonjic | 6-3 7-6 |
| 2007 | 2007-10-22 | Basel | ATP doubles | Hard | Bob Bryan / Mike Bryan | James Blake / Mark Knowles | 6-1 6-1 |
| 2007 | 2007-10-15 | Madrid | ATP doubles | Hard | Bob Bryan / Mike Bryan | Mariusz Fyrstenberg / Marcin Matkowski | 6-3 7-6 |
| 2007 | 2007-07-29 | Washington | ATP doubles | Hard | Bob Bryan / Mike Bryan | Jonathan Erlich / Andy Ram | 7-6 3-6 10-7 |
| 2007 | 2007-07-16 | Los Angeles | ATP doubles | Hard | Bob Bryan / Mike Bryan | Scott Lipsky / David Martin | 7-6 6-2 |
| 2007 | 2007-05-14 | Hamburg Masters | ATP doubles | Clay | Bob Bryan / Mike Bryan | Paul Hanley / Kevin Ullyett | 6-3 6-4 |
| 2007 | 2007-04-15 | Monte Carlo | ATP doubles | Clay | Bob Bryan / Mike Bryan | Julien Benneteau / Richard Gasquet | 6-2 6-1 |
| 2007 | 2007-04-09 | Houston | ATP doubles | Clay | Bob Bryan / Mike Bryan | Mark Knowles / Daniel Nestor | 7-6 6-4 |
| 2007 | 2007-03-19 | Miami | ATP doubles | Hard | Bob Bryan / Mike Bryan | Martin Damm / Leander Paes | 6-7 6-3 10-7 |
| 2007 | 2007-02-26 | Las Vegas | ATP doubles | Hard | Bob Bryan / Mike Bryan | Jonathan Erlich / Andy Ram | 7-6 6-2 |
| 2007 | 2007-01-15 | Australian Open | ATP doubles | Hard | Bob Bryan / Mike Bryan | Jonas Bjorkman / Max Mirnyi | 7-5 7-5 |
| 2006 | 2006-10-16 | Madrid | ATP doubles | Hard | Bob Bryan / Mike Bryan | Mark Knowles / Daniel Nestor | 7-5 6-4 |
| 2006 | 2006-08-07 | Canada | ATP doubles | Hard | Bob Bryan / Mike Bryan | Paul Hanley / Kevin Ullyett | 6-3 7-5 |
| 2006 | 2006-07-31 | Washington | ATP doubles | Hard | Bob Bryan / Mike Bryan | Paul Hanley / Kevin Ullyett | 6-3 5-7 10-3 |
| 2006 | 2006-07-24 | Los Angeles | ATP doubles | Hard | Bob Bryan / Mike Bryan | Eric Butorac / Jamie Murray | 6-2 6-4 |
| 2006 | 2006-06-26 | Wimbledon | ATP doubles | Grass | Bob Bryan / Mike Bryan | Fabrice Santoro / Nenad Zimonjic | 6-3 4-6 6-4 6-2 |
| 2006 | 2006-02-27 | Las Vegas | ATP doubles | Hard | Bob Bryan / Mike Bryan | Jaroslav Levinsky / Robert Lindstedt | 6-3 6-2 |
| 2006 | 2006-01-16 | Australian Open | ATP doubles | Hard | Bob Bryan / Mike Bryan | Martin Damm / Leander Paes | 4-6 6-3 6-4 |
| 2005 | 2005-10-31 | Paris | ATP doubles | Carpet | Bob Bryan / Mike Bryan | Mark Knowles / Daniel Nestor | 6-4 6-7 6-4 |
| 2005 | 2005-08-29 | US Open | ATP doubles | Hard | Bob Bryan / Mike Bryan | Jonas Bjorkman / Max Mirnyi | 6-1 6-4 |
| 2005 | 2005-08-01 | Washington | ATP doubles | Hard | Bob Bryan / Mike Bryan | Wayne Black / Kevin Ullyett | 6-4 6-2 |
| 2005 | 2005-06-06 | Queen's Club | ATP doubles | Grass | Bob Bryan / Mike Bryan | Jonas Bjorkman / Max Mirnyi | 7-6 7-6 |
| 2005 | 2005-02-21 | Scottsdale | ATP doubles | Hard | Bob Bryan / Mike Bryan | Wayne Arthurs / Paul Hanley | 7-5 6-4 |
| 2004 | 2004-11-15 | Tour Finals | ATP doubles | Hard | Bob Bryan / Mike Bryan | Wayne Black / Kevin Ullyett | 4-6 7-5 6-4 6-2 |
| 2004 | 2004-10-25 | Basel | ATP doubles | Carpet | Bob Bryan / Mike Bryan | Lucas Arnold Ker / Mariano Hood | 7-6 6-2 |
| 2004 | 2004-07-12 | Los Angeles | ATP doubles | Hard | Bob Bryan / Mike Bryan | Wayne Arthurs / Paul Hanley | 6-3 7-6 |
| 2004 | 2004-06-07 | Queen's Club | ATP doubles | Grass | Bob Bryan / Mike Bryan | Mark Knowles / Daniel Nestor | 6-4 6-4 |
| 2004 | 2004-03-01 | Acapulco | ATP doubles | Clay | Bob Bryan / Mike Bryan | Juan Ignacio Chela / Nicolas Massu | 6-2 6-3 |
| 2004 | 2004-02-16 | Memphis | ATP doubles | Hard | Bob Bryan / Mike Bryan | Jeff Coetzee / Chris Haggard | 6-3 6-4 |
| 2003 | 2003-11-10 | Tour Finals | ATP doubles | Hard | Bob Bryan / Mike Bryan | Michael Llodra / Fabrice Santoro | 6-7 6-3 3-6 7-6 6-4 |
| 2003 | 2003-08-11 | Cincinnati | ATP doubles | Hard | Bob Bryan / Mike Bryan | Wayne Arthurs / Paul Hanley | 7-5 7-6 |
| 2003 | 2003-06-16 | Nottingham | ATP doubles | Grass | Bob Bryan / Mike Bryan | Joshua Eagle / Jared Palmer | 7-6 4-6 7-6 |
| 2003 | 2003-05-26 | Roland-Garros | ATP doubles | Clay | Bob Bryan / Mike Bryan | Paul Haarhuis / Yevgeny Kafelnikov | 7-6 6-3 |
| 2003 | 2003-04-21 | Barcelona | ATP doubles | Clay | Bob Bryan / Mike Bryan | Chris Haggard / Robbie Koenig | 6-4 6-3 |
| 2002 | 2002-10-21 | Basel | ATP doubles | Carpet | Bob Bryan / Mike Bryan | Mark Knowles / Daniel Nestor | 7-6 7-5 |
| 2002 | 2002-07-29 | Canada | ATP doubles | Hard | Bob Bryan / Mike Bryan | Mark Knowles / Daniel Nestor | 4-6 7-6 6-3 |
| 2002 | 2002-07-08 | Newport | ATP doubles | Grass | Bob Bryan / Mike Bryan | Jurgen Melzer / Alexander Popp | 7-5 6-3 |
| 2002 | 2002-03-04 | Scottsdale | ATP doubles | Hard | Bob Bryan / Mike Bryan | Mark Knowles / Daniel Nestor | 7-5 7-6 |
| 2002 | 2002-02-25 | Acapulco | ATP doubles | Clay | Bob Bryan / Mike Bryan | Martin Damm / David Rikl | 6-1 3-6 10-2 |
| 2001 | 2001-07-23 | Los Angeles | ATP doubles | Hard | Bob Bryan / Mike Bryan | Jan Michael Gambill / Andy Roddick | 7-5 7-6 |
| 2001 | 2001-07-09 | Newport | ATP doubles | Grass | Bob Bryan / Mike Bryan | Andre Sa / Glenn Weiner | 6-3 7-5 |
| 2001 | 2001-06-11 | Queen's Club | ATP doubles | Grass | Bob Bryan / Mike Bryan | Eric Taino / David Wheaton | 6-3 3-6 6-1 |
| 2001 | 2001-02-19 | Memphis | ATP doubles | Hard | Bob Bryan / Mike Bryan | Alex Obrien / Jonathan Stark | 6-3 7-6 |